{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:27:50Z","timestamp":1781072870368,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010344","name":"Aage og Johanne Louis-Hansens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010344","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The oncological benefits of Laparoscopic Complete Mesocolic Excision (LCME) over conventional surgery are often challenged by single\u2010centre designs, small cohorts or short and incomplete follow\u2010up. This study aimed to examine the difference in recurrence risk 5\u2009years after surgery and 30\u2010day postoperative complications before and after a population\u2010based, multicentre LCME implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>LCME was implemented in the Central Denmark Region, Denmark following a training programme in 2017 for all colon cancer surgeons. Colon cancer patients from before (2015\u20132016, PRE\u2010group) and after the implementation (2018\u20132019, POST\u2010group) were identified through the Danish Colorectal Cancer Group Database. Recurrence 5\u2009years after surgery was ascertained through national registers using a validated algorithm. The Aalen\u2010Johansen estimator for competing risk was used to calculate cumulative incidence of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1919 patients (PRE,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091024; POST,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009895) underwent curative\u2010intended surgery in the study period. The 5\u2010year cumulative incidence of recurrence was 16.1% (95% CI: 13.8, 18.4) in the PRE group and 12.5% (95% CI: 10.2, 14.9) in the POST group, with a significant absolute risk difference of 3.6% (95% CI: 0.3, 6.9). Furthermore, a significantly lower hazard rate of recurrence was observed in stage II patients after the LCME implementation, with a hazard rate ratio of 0.42 (95% Cl: 0.24, 0.72). Risk of severe postoperative complications was also significantly lower in the POST, compared to the PRE group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LCME implementation was associated with a significantly lower risk of recurrence and lower rate of severe postoperative complications. This study indicates that multicentre LCME implementation may improve clinical outcomes without compromising patient safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70380","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:47:20Z","timestamp":1770616040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Five\u2010year recurrence and postoperative complications after laparoscopic complete Mesocolic excision: A population\u2010based, multicentred study"],"prefix":"10.1111","volume":"28","author":[{"given":"Tora","family":"Haug","sequence":"first","affiliation":[{"name":"Department of Surgery G\u00f8dstrup Hospital  Herning Denmark"},{"name":"NIDO | Centre for Research and Education G\u00f8dstrup Hospital  Denmark"},{"name":"Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-7179","authenticated-orcid":false,"given":"Jan Brink","family":"Valentin","sequence":"additional","affiliation":[{"name":"Danish Center for Health Services Research, Department of Clinical Medicine Aalborg University  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai\u2010Britt Worm","family":"\u00d8rntoft","sequence":"additional","affiliation":[{"name":"Department of Surgery G\u00f8dstrup Hospital  Herning Denmark"},{"name":"NIDO | Centre for Research and Education G\u00f8dstrup Hospital  Denmark"},{"name":"Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2336-2923","authenticated-orcid":false,"given":"Lene Hjerrild","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aarhus Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Paaske","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Danish Center for Health Services Research, Department of Clinical Medicine Aalborg University  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3502-792X","authenticated-orcid":false,"given":"Robin","family":"Kennedy","sequence":"additional","affiliation":[{"name":"St Mark's Hospital, Northwick Park  Harrow England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Miskovic","sequence":"additional","affiliation":[{"name":"St Mark's Hospital, Northwick Park  Harrow England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Husted","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Surgery G\u00f8dstrup Hospital  Herning Denmark"},{"name":"NIDO | Centre for Research and Education G\u00f8dstrup Hospital  Denmark"},{"name":"Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20101318.2008.01735.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(14)71168\u20104"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(19)30485\u20101"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15601"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000003012"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znac379"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(20)30685\u20109"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10083"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000777"},{"key":"e_1_2_13_11_1","unstructured":"Equator Network.The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies 2007. 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