{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:45:50Z","timestamp":1772999150554,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colorectal mucinous adenocarcinoma (MAC) is challenging due to its unique pathophysiology and increasing incidence in younger populations. Treatment guidelines for early\u2010onset MAC remain unclear, with clinical decisions often based on extrapolated data from classical adenocarcinoma. We aimed to assess the association between the extent of surgical resection and systemic therapy in patients with early\u2010onset colonic MAC and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort analysis of patients aged 20\u201350 with stage II\u2013III colonic MAC using the SEER database (2000\u20132020). We evaluated overall survival (OS) and cancer\u2010specific survival (CSS) based on surgical resection (segmental vs. extended) and systemic therapy, using Kaplan\u2013Meier and Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort\u00a0included\u00a02553 patients (58.5% male; mean age 42.7\u2009years). Segmental resection was performed in 27.6%. Extended resection was more commonly performed in right\u2010sided and stage III disease. Systemic therapy was administered to 62.1%, predominantly for stage III disease with unfavourable tumour features. Systemic therapy was associated with improved restricted mean 5\u2010year CSS (51.7 vs. 47.8\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041) and OS (51.1 vs. 45.9\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) in stage III, but not stage II, disease. Extended resection was associated with a\u00a0modest\u00a0survival benefit for CSS (56.5 vs. 54.3\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027) and OS (56.0 vs. 53.3\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) in stage II, but not stage III, disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systemic therapy was associated with a significant survival benefit in patients with stage III early\u2010onset MAC, supporting its role as a cornerstone of treatment despite the histology's presumed chemoresistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70390","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:20:32Z","timestamp":1771060832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimizing treatment strategies for early\u2010onset mucinous adenocarcinoma of the colon: A\n                    <scp>SEER<\/scp>\n                    database analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Cameron","family":"Perrone","sequence":"first","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida  Weston Florida USA"},{"name":"Charles E. Schmidt College of Medicine Florida Atlantic University  Boca Raton Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh Hany","family":"Emile","sequence":"additional","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida  Weston Florida USA"},{"name":"Colorectal Surgery Unit, General Surgery Department Mansoura University Hospitals  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Lopez","sequence":"additional","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida  Weston Florida USA"},{"name":"Charles E. Schmidt College of Medicine Florida Atlantic University  Boca Raton Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer","family":"Barnes","sequence":"additional","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida  Weston Florida USA"},{"name":"Charles E. Schmidt College of Medicine Florida Atlantic University  Boca Raton Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjelli","family":"Wignakumar","sequence":"additional","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Bilotti","sequence":"additional","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida  Weston Florida USA"},{"name":"Charles E. Schmidt College of Medicine Florida Atlantic University  Boca Raton Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8046-5753","authenticated-orcid":false,"given":"Steven D.","family":"Wexner","sequence":"additional","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida  Weston Florida USA"},{"name":"Department of Colorectal Surgery Medstar Georgetown University Health  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113193"},{"key":"e_1_2_12_3_1","unstructured":"WangL.Possible signs of colorectal cancer in younger adults\u2014NCI. www.cancer.gov.2023Published June 15 2023. Available from:https:\/\/www.cancer.gov\/news\u2010events\/cancer\u2010currents\u2010blog\/2023\/colorectal\u2010cancer\u2010young\u2010people\u2010warning\u2010signs"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v13.i12.1567"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","unstructured":"HanF XuY LiX SongZ XieJ YaoJ.Clinicopaothological features and prognosis analysis of proximal colonic mucinous adenocarcinoma.2024Nature News August 12 2024.","DOI":"10.1038\/s41598-024-69916-0"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010019\u201002019\u2010x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr062"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9098(200010)75:2<103::AID-JSO6>3.0.CO;2-C"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2017.03.001"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0029"},{"key":"e_1_2_12_11_1","unstructured":"F\u20100 SEER program code manual 3rd edition revision 1 (2003) SEER site\u2010specific surgery of primary site codes SEER program code manual 3rd edition revision 1. Accessed July 22 2024.https:\/\/seer.cancer.gov\/archive\/tools\/SEER2003.surg.prim.site.codes.pdf"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880\u2010019\u20100361\u20100"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487710"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107819\u201010\u2010109"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030803"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v15.i8.1461"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201047548\u2010z"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151\u2010023\u201002796\u20100"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350\u2010008\u20109325\u20101"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.s158335"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.70390","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:04:53Z","timestamp":1772989493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.70390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/codi.70390"],"URL":"https:\/\/doi.org\/10.1111\/codi.70390","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70390"}}