{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:45:41Z","timestamp":1772999141314,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of surgical site infections (SSIs) has been reported to be significantly higher in colorectal surgeries compared to other surgical procedures. Wound protectors have been developed to help reduce the incidence of SSIs by creating a barrier between the incisional wound and the contaminated surgical field, but their efficacy remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess whether the use of wound protectors reduces the incidence of SSIs in patients undergoing open colorectal surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>A comprehensive literature review was conducted using PubMed, Embase, Web of Science and Cochrane databases from inception to January 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection<\/jats:title>\n                    <jats:p>Randomised controlled trials (RCTs) assessing the efficacy of wound protectors for reducing the incidence of SSIs in patients undergoing open colorectal surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>The intervention consisted of wound protectors (e.g., Alexis O\u2010ring wound retractors, plastic ring drape).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcomes Measures<\/jats:title>\n                    <jats:p>The main outcome was SSI. We pooled risk ratios (RRs) with a 95% confidence interval (CI) using a random effects model. Statistical analysis was performed using R software (version 4.4.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 6 RCTs comprising 666 patients, of whom 327 (49 %) were randomised to the wound protectors\u2019 group. The mean follow\u2010up duration was 30\u2009days post\u2010operatively. The incidence of SSIs was significantly lower in the intervention group (RR 0.44; 95% CI 0.22\u20130.88;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021). Subgroup analysis of four RCTs evaluating Alexis\u2010O ring wound retractors showed a significantly lower incidence of SSIs in the experimental group (RR 0.21; 95% CI 0.09\u20130.48;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Wound protectors were associated with a significantly lower incidence of SSIs in patients undergoing open colorectal surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70401","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:11:13Z","timestamp":1771060273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of wound protectors in reducing surgical site infections in patients undergoing open colorectal surgery: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4566-2967","authenticated-orcid":false,"given":"Arusha","family":"Desai","sequence":"first","affiliation":[{"name":"Department of Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of General Surgery Armed Forces Medical College  Pune Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9937-3873","authenticated-orcid":false,"given":"Rahul","family":"Bisht","sequence":"additional","affiliation":[{"name":"Department of General Surgery Armed Forces Medical College  Pune Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3985-8595","authenticated-orcid":false,"given":"Sidharth","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of General Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5508-5107","authenticated-orcid":false,"given":"Mangesh","family":"Kritya","sequence":"additional","affiliation":[{"name":"Department of Structural Heart Disease Houston Methodist Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soubhik","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejaswini","family":"Pisipati","sequence":"additional","affiliation":[{"name":"Department of Obstetrics 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