{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:51:25Z","timestamp":1790704285583,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014197","name":"Stiftelsen Mary von Sydows, f\u00f6dd Wijk, donationsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 2016\/509"],"award-info":[{"award-number":["CAN 2016\/509"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["190333"],"award-info":[{"award-number":["190333"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["222265"],"award-info":[{"award-number":["222265"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Frailty is known to adversely affect post\u2010operative mortality and morbidity following colorectal cancer resection, but its impact on long\u2010term quality of life and functional outcomes after colon cancer surgery is less clear. This study aims to evaluate the impact of frailty at the time of diagnosis on quality of life, impact on daily activities, and contentment with treatment one year after colon cancer resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Data were obtained from the prospective, multicentre Quality of Life in Colon Cancer (QoLiCOL) study. Patients aged \u226570\u2009years who underwent colon cancer surgery in Region V\u00e4stra G\u00f6taland, Sweden, were collected from the QoLiCOL database (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009347). Clinical data were retrieved from national quality registries. Frailty was retrospectively assessed by reviewing medical records using the Clinical Frailty Scale\u20109 (CFS\u20109), with scores \u22654 classified as frail. Outcomes included self\u2010reported quality of life, treatment\u2010related impact on activities of daily living, and treatment satisfaction one year post\u2010operatively. Directed Acyclic Graphs (DAGs) of variables known to affect the outcome variables were made before analyses, and potential confounders were adjusted for in the final analyses. Comparisons between frail and non\u2010frail groups were performed using ordinal logistic regression and logistic regression, with results reported as odds ratios (OR).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of frailty in the cohort was 29%, with a median CFS\u20109 value of 4 (range 4\u20136) in the frail group, indicating very mild to moderate frailty. No significant differences were observed between frail and non\u2010frail older adults in self\u2010assessed quality of life, treatment\u2010related impact on daily activities or treatment satisfaction one year after surgery. Notably, both groups reported improved quality of life at one year compared with baseline. Only a small proportion of participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098; 2%) reported not being content with their treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among older adults who were alive one year after colon cancer surgery, mild to moderate frailty does not appear to negatively influence long\u2010term quality of life, effect on daily activities, or satisfaction with treatment. Frail and non\u2010frail patients reported similar levels of well\u2010being and contentment with their care one year post\u2010operatively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70438","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:04:07Z","timestamp":1775559847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mild to moderate frailty among older adults does not affect long\u2010term quality of life or functional outcomes after colon cancer surgery"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5426-2861","authenticated-orcid":false,"given":"Maria","family":"Normann","sequence":"first","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Surgery NU\u2010Hospital Group  Trollh\u00e4ttan Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Haglind","sequence":"additional","affiliation":[{"name":"Department of Surgery, SSORG \u2013 Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Surgery Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4939-4189","authenticated-orcid":false,"given":"Peter","family":"Matthiessen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Department of Surgery \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Department of Surgery \u00d6rebro University Hospital  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-1086","authenticated-orcid":false,"given":"Jacob","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Surgery, Herlev Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Ekerstad","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Research and Development NU\u2010Hospital Group  Trollh\u00e4ttan Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Angenete","sequence":"additional","affiliation":[{"name":"Department of Surgery, SSORG \u2013 Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Surgery Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Prytz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Surgery NU\u2010Hospital Group  Trollh\u00e4ttan Sweden"},{"name":"Department of Research and Development NU\u2010Hospital Group  Trollh\u00e4ttan Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Interaktiv rapport tjocktarmscancer","author":"Swedish Colorectal Cancer Registry","year":"2025"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32319-0"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.65"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/18735592MTEx9NTk2y"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrac094"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2014.10.001"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-024-03316-6"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62167-9"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2016.06.001"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2018.07.009"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v16.i3.893"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.28137"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0237"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-021-02221-6"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2015-206717"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-023-03537-4"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2003.12.010"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2020.08.001"},{"issue":"4","key":"e_1_2_13_21_1","first-page":"214","article-title":"Preoperative assessment in older adults: a comprehensive approach","volume":"98","author":"Kumar C","year":"2018","journal-title":"Am Fam Physician"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02195"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa012528"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2016.03.002"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3180caa3fb"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0725-9"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.03915.x"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2013.08.001"},{"key":"e_1_2_13_29_1","unstructured":"clinicalTrials.gov NCT02530593. Available from:https:\/\/clinicaltrials.gov\/study\/NCT02530593?term=qolicol&rank=1"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.2340\/1651-226X.2024.40933"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000003358"},{"issue":"5","key":"e_1_2_13_32_1","article-title":"Self\u2010reported quality of life and functional outcome in patients with rectal cancer\u2014QoLiRECT","volume":"61","author":"Asplund D","year":"2014","journal-title":"Dan Med J"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-023-04525-6"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.5770\/cgj.23.463"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.5770\/cgj.21.263"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-022-00686-6"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2018.02.004"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/geriatrics5020040"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03632-3"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.70438","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:01:59Z","timestamp":1776747719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.70438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/codi.70438"],"URL":"https:\/\/doi.org\/10.1111\/codi.70438","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70438"}}