{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:46:16Z","timestamp":1789469176839,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Treatment of complex anal fistulae remains a significant challenge for physicians and patients. A sphincter\u2010preserving technique with bioactive platelet\u2010rich fibrin matrix is one option. This three\u2010year study aimed to evaluate the efficacy of bioactive platelet\u2010rich fibrin matrix in treating complex anal fistulae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This retrospective study analysed data from 2019 to 2022 of patients diagnosed with complex anal fistulae treated with a platelet\u2010rich fibrin matrix at a tertiary centre. Endoanal ultrasound was used to morphologically characterize fistulas using Park's classification. Pearson's chi\u2010squared and Kaplan\u2013Meier (log\u2010rank) analyses were used to evaluate between\u2010group differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 213 patients were included in the study (181 with cryptoglandular fistulae and 32 with Crohn's disease\u2010associated fistulae) with a median follow\u2010up of 6.6\u2009months (range 0.5\u201367.1\u2009months). Cavities and secondary tracts were identified in 14.6% and 34.7% of the patients, respectively. External opening closure occurred in 32% after one procedure and 43% cumulatively after a second intervention. Healing rates did not differ statistically by aetiology or fistula location. Cavities and secondary tracts were associated with failure. During follow\u2010up, 23% of the secondary tracts healed, whereas cavities derived no significant benefit from the intervention. No serious complications were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Platelet\u2010rich fibrin matrix is a simple and safe sphincter\u2010preserving technique that achieves reasonably good results in the treatment of cryptoglandular and Crohn's disease\u2010associated fistulae. While secondary tracts may respond well, further research is required to optimize the management of fistulae associated with cavities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70447","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:34:10Z","timestamp":1775266450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Platelet\u2010rich fibrin matrix as treatment for complex anal fistulae: A 3\u2010year experience at a tertiary centre"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2164-6459","authenticated-orcid":false,"given":"Alejandro","family":"Lusilla Lopez","sequence":"first","affiliation":[{"name":"Department of Surgery Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 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