{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T06:05:51Z","timestamp":1779516351512,"version":"3.53.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Strategies to optimise bowel function before stoma reversal surgery (SRS) are needed to improve postoperative outcomes. Efferent bowel stimulation (EBS) prior to stoma closure has been proposed as a potential strategy to reduce postoperative ileus (POI) incidence and improve the patient's postoperative course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicentre randomised controlled trial was designed to evaluate the effectiveness of pre\u2010SRS EBS in reducing POI incidence. Patients scheduled for elective SRS were randomised 1:1 to either an intervention group, receiving daily EBS with saline and a nutritional thickener for 2\u2009weeks preoperatively, or a control group, undergoing SRS without stimulation. The primary endpoint was POI incidence. Secondary outcomes included the time to oral diet tolerance, passage of first flatus\/stool, surgery\u2010related comorbidities, length of hospital stay and incidence of Low Anterior Resection Syndrome (LARS) (NCT05302557\u201031\/03\/2022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From June 2021 to April 2023, 175 patients were enrolled from 18 hospitals in Spain, 78 (44.5%) and 97 (55.4%) of whom were allocated to the intervention and control groups, respectively. We found that EBS was not significantly associated with a decrease in POI incidence (7.6% vs. 16.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.088). No significant differences in the median hospital stay (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.545) or LARS at discharge (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.087) were observed between the two groups. The EBS group showed fewer but more severe complications (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative EBS is a feasible and reproducible intervention that may represent a potential strategy to reduce POI following SRS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70448","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:20:41Z","timestamp":1778127641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <scp>ILEOSTIM<\/scp>\n                    trial: A multicentre randomised controlled trial evaluating the impact of efferent loop stimulation prior to ileostomy reversal on postoperative ileus"],"prefix":"10.1111","volume":"28","author":[{"given":"Jorge","family":"Arredondo","sequence":"first","affiliation":[{"name":"Department of General Surgery Cl\u00ednica Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2798-5204","authenticated-orcid":false,"given":"Adriana","family":"Uriz","sequence":"additional","affiliation":[{"name":"Department of General Surgery Cl\u00ednica Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Oliva","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Universitario de Le\u00f3n  Le\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 I.","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-6727","authenticated-orcid":false,"given":"Christian N.","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Universitario de Cabue\u00f1es  Gij\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekta","family":"Choolani","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Universitario R\u00edo Hortega  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa","family":"Valle","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Universitario de Getafe  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Rivera","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Universitario de Canarias  Tenerife 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Tasende","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Universitario Son Llatzer  Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Nuestra Se\u00f1ora del Prado  Talavera de la Reina Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Montcus\u00ed","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Tejedor","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9889-7116","authenticated-orcid":false,"given":"Jeancarlos","family":"Trujillo\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Medina del Campo  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia Ruiz","family":"de la Hermosa","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Universitario Infanta Leonor  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Baixauli","sequence":"additional","affiliation":[{"name":"Department of General Surgery Cl\u00ednica Universidad de Navarra  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