{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T06:05:52Z","timestamp":1779516352567,"version":"3.53.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000297","name":"Royal College of Surgeons of England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Rectal intussusception (RI), proposed to be a progressive condition, is associated with internal sphincter dysfunction. This study examines sphincter function using anal acoustic reflectometry (AAR) at long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective study of conservatively managed patients attending a tertiary pelvic floor unit. Clinical, AAR and symptom severity data were analysed at baseline and follow\u2010up (&gt;5\u2009years). Patients were grouped into intra\u2010rectal (Oxford I\u2013II) or intra\u2010anal RI (III\u2013IV). Data from asymptomatic volunteers were used to estimate the effect of ageing on AAR parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010nine patients (27 female; median age: 66\u2009years) were recruited, with follow\u2010up at a median of 66 (IQR: 64\u201367) months. Twelve were diagnosed with intra\u2010rectal RI and 17 with intra\u2010anal RI at baseline. No patient developed an external rectal prolapse.<\/jats:p>\n                    <jats:p>\n                      There were no differences in quality of life, faecal incontinence or constipation symptoms in either group at follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                    <jats:p>\n                      A non\u2010significant decrease in opening pressure, a measure of internal sphincter function, was seen in both intra\u2010rectal (\u22124.0 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.530) and intra\u2010anal RI (\u22123.7 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.287). In healthy volunteers, opening pressure was associated with age (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.402;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a decline of 2.90 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O (95% CI: \u22124.35 to \u22121.50) would be expected after 5\u2009years.\n                    <\/jats:p>\n                    <jats:p>\n                      Incremental squeeze opening pressure showed a non\u2010significant increase in intra\u2010rectal RI (8.4 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.099) and no change in intra\u2010anal RI (\u22121.7 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.532).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There were no significant changes in patient\u2010reported symptoms or anal sphincter function in conservatively managed RI at follow\u2010up, challenging the concept of a progressive condition with a detrimental impact on sphincter function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70455","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:28:37Z","timestamp":1777544917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anal sphincter function in conservatively managed rectal intussusception at long\u2010term follow\u2010up: A prospective anal acoustic reflectometry study with comparison to healthy volunteer data"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3964-9152","authenticated-orcid":false,"given":"Alexander","family":"O'Connor","sequence":"first","affiliation":[{"name":"Faculty of Biology, Medicine, and Health The University of Manchester  Manchester UK"},{"name":"Department of Colorectal Surgery Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1341-562X","authenticated-orcid":false,"given":"Matthew","family":"Davenport","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine, and Health The University of Manchester  Manchester UK"},{"name":"Department of Colorectal Surgery Manchester University NHS Foundation Trust  Manchester 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