{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:30:23Z","timestamp":1780421423402,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colon cancer treatment has evolved significantly through earlier detection, less invasive surgery, optimised perioperative care and shortening chemotherapy duration from 6 to 3\u2009months in 2017. These multidisciplinary improvements may contribute to better health\u2010related quality of life (HRQoL), yet population\u2010based data on their real\u2010world impact on HRQoL and functional outcomes remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study used data from the Dutch Prospective PLCRC cohort, including patients with stage I\u2013III colon cancer who completed patient\u2010reported outcome measures (PROMs) at 12 or 24\u2009months post\u2010diagnosis. HRQoL was assessed using EORTC QLQ\u2010C30, QLQ\u2010CR29 and the LARS score. Patients diagnosed in 2014\u20132016 (Group A) were compared with those from 2017 to 2019 (Group B). Propensity score matching (1:4) was applied for age, sex and tumour stage. Multivariable analyses were adjusted accordingly, minimally important differences (MIDs) guided clinical relevance and the values were compared with Dutch population values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1,749 patients were included in the analysis. Following propensity score matching, no clinically meaningful differences in the EORTC QLQ\u2010C30 functional or symptom scales were observed at 12\u2009months post\u2010diagnosis between patients diagnosed in 2014\u20132016 (Group A) and those diagnosed in 2017\u20132019 (Group B). At 24\u2009months, Group B demonstrated a modestly better QLQ\u2010C30 summary score (mean difference\u2009+\u20091.3; 95% CI: 0.6\u20131.9), as well as statistically significant but clinically negligible improvements in role and cognitive functioning, and lower reported levels of fatigue, appetite loss and financial difficulties. Functional outcomes assessed via QLQ\u2010CR29 and LARS score were comparable between groups, with a non\u2010significant trend towards fewer major LARS cases in Group B at 24\u2009months (14.6% vs. 19.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.068).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dutch colon cancer patients reported good HRQoL and functional outcomes up to 2\u2009years post\u2010diagnosis, with no clinically relevant differences between 2014\u20132016 and 2017\u20132019. These findings suggest a consistently high standard of care nationwide. Ongoing monitoring remains essential to address individual symptom burden and evaluate the impact of evolving treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70461","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T08:54:48Z","timestamp":1777020888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Health\u2010related quality of life and functional outcomes of colon cancer patients in the Netherlands: A population\u2010based study"],"prefix":"10.1111","volume":"28","author":[{"given":"A. J.","family":"Pennings","sequence":"first","affiliation":[{"name":"Department of Surgery Maastricht University Medical Centre  Maastricht the Netherlands"},{"name":"GROW School for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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L.","family":"Beets","sequence":"additional","affiliation":[{"name":"GROW School for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"},{"name":"Department of Surgery Netherlands Cancer Institute\u2010Antoni Van Leeuwenhoek  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-3790","authenticated-orcid":false,"given":"A. M.","family":"May","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Julius Center for Health Sciences and Primary Care University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. O.","family":"Breukink","sequence":"additional","affiliation":[{"name":"Department of Surgery Maastricht University Medical Centre  Maastricht the Netherlands"},{"name":"GROW School for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"(IKNL) NCCO.Numbers of colorectal cancer: Netherlands Comprehensive Cancer Organisation (IKNL). Available from:https:\/\/iknl.nl\/nkr\u2010cijfers."},{"key":"e_1_2_14_3_1","unstructured":"Specialisten FM.Dutch National Guideline Colorectal carcinoma (CRC).2021. 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