{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:23:34Z","timestamp":1787387014253,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["9030"],"award-info":[{"award-number":["9030"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To identify distinct health\u2010related quality of life (HRQoL) profiles among colorectal cancer (CRC) patients using patient\u2010reported outcome measures (PROMs), with the aim of informing more personalised follow\u2010up strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baseline HRQoL data from CRC patients enrolled in the FUTURE\u2010primary study, a multicentre implementation study on home\u2010based follow\u2010up, were analysed. Patients completed the EORTC QLQ\u2010C30 and QLQ\u2010CR29 questionnaires. Aggregated symptom and function scales were developed using factor analysis and expert consensus. Latent profile analysis (LPA) was applied to identify subgroups based on PROM responses. Model selection was guided by the Bayesian Information Criterion (BIC), entropy, average posterior probabilities (AvePP), class sizes, clinical interpretability, and additional sensitivity and stability analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three HRQoL profiles were identified: low HRQoL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200962), intermediate HRQoL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200995), and high HRQoL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942). The profiles followed a gradient\u2010like pattern, with consistently high, moderate, or low scores across symptom burden and functional outcomes. Classification quality was high, as indicated by high entropy (&gt;0.93) and average posterior probabilities (&gt;0.96), although profile assignment should be interpreted probabilistically.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights variation in HRQoL among CRC patients. LPA identified three profiles that primarily reflected differences in overall symptom burden and functioning. These profiles may provide a preliminary framework for describing differences in supportive care needs, but their clinical applicability for tailoring follow\u2010up or allocating care resources requires longitudinal validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for Cancer Survivors<\/jats:title>\n                    <jats:p>Identifying HRQoL profiles may support more personalised follow\u2010up, ensuring targeted care for those with higher symptom burden and lower functional scores, while reducing unnecessary interventions for others.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70553","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:34:12Z","timestamp":1784871252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of life assessment for colorectal cancer follow\u2010up: A latent profile analysis of\n                    <scp>EORTC<\/scp>\n                    measures"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8710-094X","authenticated-orcid":false,"given":"M. H. Elise van","family":"Driel","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissa","family":"Wullaert","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly R.","family":"Voigt","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7229-0073","authenticated-orcid":false,"given":"Pascal G.","family":"Doornebosch","sequence":"additional","affiliation":[{"name":"Department of Surgery IJsselland Hospital  Capelle aan den IJssel The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9332-1334","authenticated-orcid":false,"given":"Koen C. M. J.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M. J.","family":"Schreinemakers","sequence":"additional","affiliation":[{"name":"Department of Surgery Amphia Hospital  Breda The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-6444","authenticated-orcid":false,"given":"Maria","family":"Verseveld","sequence":"additional","affiliation":[{"name":"Department of Surgery Franciscus Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9980-8613","authenticated-orcid":false,"given":"Cornelis","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8293-6002","authenticated-orcid":false,"given":"Dirk J.","family":"Gr\u00fcnhagen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Husson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Netherlands Cancer Institute (NKI)  Amsterdam The Netherlands"},{"name":"Department of Public Health Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-9973","authenticated-orcid":false,"given":"Martijn A. 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