{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:23:29Z","timestamp":1787387009591,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004635","name":"Fru Berta Kamprads Stiftelse","doi-asserted-by":"publisher","award":["2022\u20103\u2010363"],"award-info":[{"award-number":["2022\u20103\u2010363"]}],"id":[{"id":"10.13039\/501100004635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n A prolonged time from diagnosis to start of radiotherapy (TTRT) for malignant disease may negatively influence survival, but studies in squamous cell carcinoma of the anus (SCCA) are largely lacking. The purpose of this study was to investigate the impact of TTRT on overall survival (OS) and anal cancer\u2010specific survival (ACSS) in a nationwide population\u2010based cohort from the Swedish Anal Cancer Registry.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Patients with non\u2010metastatic SCCA treated with curative intent definitive radiotherapy (93.3% concomitant chemotherapy) during 2015\u20132023 were included (\n n<\/jats:italic>\n \u2009=\u2009958). According to national guidelines TTRT should be \u2264\u200946\u2009days and this was used as a cut\u2010off in the primary analyses. Cox proportional hazards models were used to estimate hazard ratios for OS and ACSS. Variables with\n p<\/jats:italic>\n \u2009<\u20090.10 in univariable analyses were entered into multivariable models, with TTRT included in all models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The median TTRT was 48\u2009days (range 17\u2013350), and in 55% of the patients it exceeded 46\u2009days. Old age, poor performance status, small tumour size, absence of lymph node metastasis and no concomitant chemotherapy were associated with TTRT >46\u2009days. With a median follow\u2010up of 43\u2009months, TTRT >\u200946\u2009days had no impact on OS or ACSS. Sensitivity analyses using alternative TTRT cut\u2010offs and restricting the analysis to high\u2010risk subgroups showed similar results.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Moderate delays beyond 46\u2009days from diagnosis to radiotherapy initiation did not adversely affect OS or ACSS in patients with SCCA.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/codi.70569","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T04:44:52Z","timestamp":1786596292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of time from diagnosis to start of radiotherapy in anal cancer"],"prefix":"10.1111","volume":"28","author":[{"given":"Jakob","family":"Hallstr\u00f6m","sequence":"first","affiliation":[{"name":"Division of Oncology and Pathology, Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Department of Hematology, Oncology and Radiation Physics Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Johnsson","sequence":"additional","affiliation":[{"name":"Division of Oncology and Pathology, Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Department of Hematology, Oncology and Radiation Physics Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7419-6750","authenticated-orcid":false,"given":"Martin P.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Division of Oncology and Pathology, Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Department of Hematology, Oncology and Radiation Physics Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2022.2048069"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0030"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4087"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.11.016"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000961"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-01645-w"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860310014886"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16638"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2021.1992006"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.08.032"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1001843"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-23-256"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2016.07.010"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.09.030"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.107106"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2021.02.009"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02831"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2340\/1651-226X.2025.42498"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2021.1918763"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S466029"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.70569","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:45:46Z","timestamp":1787384746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.70569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/codi.70569"],"URL":"https:\/\/doi.org\/10.1111\/codi.70569","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70569"}}