{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:23:36Z","timestamp":1787387016792,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Literature comparing total proctocolectomy with permanent end ileostomy (TPC\u2010EI) and IPAA in patients with UC is sparse. We aimed to (a) elucidate reasons for non\u2010restorative surgery in ulcerative colitis (UC), (b) describe the incidence of perineal wound complications and (c) assess differences in short\u2010term outcomes between groups. We hypothesized that non\u2010restorative surgery was associated with a higher overall complication rate than ileoanal pouch (IPAA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified a sample of patients with UC who underwent proctectomy (2005\u20132023) at our institution. The primary endpoint was the overall 30\u2010day complication rate. Odds ratios (ORs) and 95% confidence intervals are presented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 821 patients were included: 689 (83.9%) IPAA and 132 (16.1%) TPC\u2010EI (80% and 52% staged proctectomy, respectively). The most common reasons for TPC\u2010EI over IPAA were patient preference (53%), neoplasia (10.6%), incontinence (9.1%) and obesity (7.6%). Compared with IPAA patients, TPC\u2010EI patients were older, had more comorbidities, and more were receiving biologics. Postoperatively, 18.2% of TPC\u2010EI patients developed perineal wound complications, whereas 4.5% of IPAA patients experienced leaks. The overall 30\u2010day complication rate was higher after TPC\u2010EI (37.1% vs. 19.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001); however, after excluding these procedure\u2010specific complications, rates were equivalent (22.7% vs. 17.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.23). In multivariable analysis after propensity score matching, TPC\u2010EI remained a significant predictor of any complication (OR 2.84, 95% CI 1.37\u20136.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patient preference was the most common reason for permanent ileostomy in UC. Although short\u2010term complication rates were similar overall, perineal complications occurred in 18% after TPC\u2010EI. These data may inform preoperative counselling when discussing surgical options for UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70571","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:42:04Z","timestamp":1785991324000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Restorative versus non\u2010restorative total proctocolectomy: Who doesn't pouch and how do they do?"],"prefix":"10.1111","volume":"28","author":[{"given":"Imran","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Colon &amp; Rectal Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Berger","sequence":"additional","affiliation":[{"name":"Columbia Surgical Specialists  Spokane WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7047-2708","authenticated-orcid":false,"given":"Arielle","family":"Kanters","sequence":"additional","affiliation":[{"name":"Department of Colon &amp; Rectal Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Lavryk","sequence":"additional","affiliation":[{"name":"Department of Colon &amp; Rectal Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6165-0304","authenticated-orcid":false,"given":"Jeremy","family":"Lipman","sequence":"additional","affiliation":[{"name":"Department of Colon &amp; Rectal Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Colon &amp; Rectal Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8632-6065","authenticated-orcid":false,"given":"David","family":"Liska","sequence":"additional","affiliation":[{"name":"Department of Colon &amp; Rectal Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-9042","authenticated-orcid":false,"given":"Stefan D.","family":"Holubar","sequence":"additional","affiliation":[{"name":"Department of Colon &amp; Rectal Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"1858","article-title":"Cumulative incidence and risk factors for hospitalization and surgery in a population\u2010based cohort of ulcerative colitis","volume":"19","author":"Samuel 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