{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:03:12Z","timestamp":1790143392026,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Treating anal high\u2010grade squamous intraepithelial lesions (HSIL) reduces squamous cell carcinoma (SCC) rates in high\u2010risk groups such as men having sex with men (MSM), especially those living with HIV (LWH). Follow\u2010up data after HSIL treatment is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted of consecutive male patients with biopsy\u2010proven HSIL undergoing high resolution anoscopy (HRA)\u2010based ablation and subsequent surveillance at a UK specialist centre until either latest HRA or cancer diagnosis. The primary objective was the proportion becoming HSIL\u2010free after treatment.<\/jats:p>\n                    <jats:p>Statistical analysis was carried out using time\u2010to\u2010event analysis with Cox proportional hazards and endpoints of anal cancer and HSIL recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 136 men, 88% MSM, 78% LWH, underwent surveillance for a median of 5.5 (interquartile range (IQR) 4.0\u20136.8) years after laser ablation of 188 HSILs of the perianus (26%) or anal canal (74%).<\/jats:p>\n                    <jats:p>\n                      After median 1 (IQR 1\u20132) ablations, 122\/136 (90%) patients became HSIL\u2010free (definition: \u2265 one HRA with cytology, free of HSIL), median 7 (IQR 5\u201314) months from index treatment. Fourteen of 136 (10%) patients never became HSIL\u2010free, of whom 5\/14 (36%) developed SCC compared to 1\/122 (0.8%) who were HSIL\u2010free at least once (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). All six patients developing SCC were MSMLWH.\n                    <\/jats:p>\n                    <jats:p>\n                      Never being HSIL\u2010free was associated with larger index lesions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a CD4 nadir of &lt;200 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                    <jats:p>At study end, 98\/130 without cancer had been HSIL recurrence free (75%) for median 31 (IQR 8\u201358) months, after total median two ablations (IQR 2\u20134).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>HRA\u2010based treatment of anal HSIL with ablation allows the majority to become HSIL\u2010free. Closer surveillance is needed for those with persisting lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70596","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:35:02Z","timestamp":1789533302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term outcome of ablation for anal\n                    <scp>HSIL<\/scp>\n                    : Achieving\n                    <scp>HSIL<\/scp>\n                    \u2010free status is key\u2014A\n                    <scp>UK<\/scp>\n                    \u2010based retrospective cohort study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3448-1426","authenticated-orcid":false,"given":"T.","family":"Cuming","sequence":"first","affiliation":[{"name":"Homerton University Hospital  London UK"},{"name":"Imperial College  London UK"},{"name":"Department of Dermatology Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-1728","authenticated-orcid":false,"given":"K.","family":"Rozemeijer","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam UMC, Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Imaging and Biomarkers Cancer Center Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Farrow","sequence":"additional","affiliation":[{"name":"Homerton University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cappello","sequence":"additional","affiliation":[{"name":"Homerton University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wait","sequence":"additional","affiliation":[{"name":"Homerton University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2458-9991","authenticated-orcid":false,"given":"M.","family":"Junejo","sequence":"additional","affiliation":[{"name":"Homerton University Hospital  London UK"},{"name":"Sloane Kettering  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bowring","sequence":"additional","affiliation":[{"name":"Homerton University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-0721","authenticated-orcid":false,"given":"A. N.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Homerton University Hospital  London UK"},{"name":"University College London Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Richel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-7657","authenticated-orcid":false,"given":"M.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Homerton University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9784-547X","authenticated-orcid":false,"given":"H. J. C.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Dermatology Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Infectious Diseases Amsterdam Institute for Infection and Immunity  Amsterdam The Netherlands"},{"name":"Department of Infectious Diseases, Center for Sexual Health Public Health Service  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Prins","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Amsterdam UMC Location University of Amsterdam  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae127"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33185"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.LGT200570"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24116"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw764"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31035"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2201048"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010020\u201003740\u20106"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000256"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(13)70067\u20106"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32581"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12352"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009244.pub3"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000058"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2007.007290"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011837.pub2"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy615"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.1999.01184.x"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_15_21_1","unstructured":"NHS Digital. Available from:https:\/\/digital.nhs.uk\/data\u2010and\u2010information\/publications\/statistical\/cancer\u2010registration\u2010statistics\/england\u20102023. Accessed 28 Dec 2025."},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102021\u2010060301"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.70596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:21:20Z","timestamp":1790140880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.70596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/codi.70596"],"URL":"https:\/\/doi.org\/10.1111\/codi.70596","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70596"}}