{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:02:56Z","timestamp":1790143376158,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011727","name":"Stockholm l\u00e4ns landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the incidence of new persistent opioid use (NPOU) after elective colorectal surgery in Sweden and to identify associated patient\u2010, procedure\u2010 and hospital\u2010level factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This nationwide retrospective cohort study linked data from Swedish national health registries and included adults undergoing elective inpatient colorectal surgery between 2018 and 2022. Patients with an opioid dispensed 365 to 30\u2009days before surgery, another surgical procedure within one year of the index operation, or death within 12\u2009months postoperatively were excluded. NPOU was defined as at least one opioid dispensed within 90\u2009days after surgery and at least one between 90 and 180\u2009days. Associations were examined using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 14,233 opioid\u2010na\u00efve patients, 374 (2.63%; 95% CI, 2.37\u20132.90%) developed NPOU. Longer operating time (aOR, 1.19 per hour; 95% CI, 1.13\u20131.26), preoperative non\u2010opioid analgesics (aOR, 1.90; 95% CI, 1.52\u20132.37) or sedatives\/anxiolytics (aOR, 1.66; 95% CI, 1.31\u20132.09), opioid dispensation within 7\u2009days of surgery (aOR, 2.19; 95% CI, 1.76\u20132.72), and higher ASA classification (ASA 3: aOR, 1.89; 95% CI, 1.26\u20132.90; ASA 4: aOR, 3.29; 95% CI, 1.63\u20136.36) were independently associated with higher odds of NPOU, whereas male sex was associated with lower odds (aOR, 0.76; 95% CI, 0.61\u20130.95).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this low\u2010prescribing setting, approximately one in 38 opioid\u2010na\u00efve patients developed NPOU 6\u2009months after colorectal surgery. Operating time and opioid dispensation within 7\u2009days of surgery were independently associated with NPOU; the latter, a modifiable prescribing decision, is a plausible target for opioid\u2010sparing strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70601","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:21:06Z","timestamp":1787635266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New persistent opioid use after colorectal surgery in Sweden: A nationwide register\u2010based cohort study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1917-4671","authenticated-orcid":false,"given":"Claes","family":"Gedda","sequence":"first","affiliation":[{"name":"Department of Surgery and Anaesthesiology Ersta Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science Danderyds Hospital, Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8239-6376","authenticated-orcid":false,"given":"Jonas","family":"Nygren","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anaesthesiology Ersta Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science Danderyds Hospital, Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2095-7048","authenticated-orcid":false,"given":"Erik","family":"Stureg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Faculty of Medicine Lund University  Malm\u00f6 Sweden"},{"name":"Department of Communicable Disease Control and Preparedness Public Health Agency of Sweden  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1165-3595","authenticated-orcid":false,"given":"Yunzhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Thorell","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anaesthesiology Ersta Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science Danderyds Hospital, Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4287-6978","authenticated-orcid":false,"given":"Mattias","family":"Soop","sequence":"additional","affiliation":[{"name":"Department of Clinical Science Danderyds Hospital, Karolinska Institute  Stockholm Sweden"},{"name":"Department of Inflammatory Bowel Disease and Intestinal Failure Surgery Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.1827"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003265"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.60794"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1251"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0504"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001429"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000006911"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-024-15435-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2025.04.019"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.06.081"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2023.05.006"},{"key":"e_1_2_11_13_1","unstructured":"CDC. National Center for Health Statistics Division of Vital Statistics.Mortality Data.2017."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2015.1016607"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-071135"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.10734"},{"key":"e_1_2_11_17_1","unstructured":"SPOR.SPOR official homepage.2025."},{"key":"e_1_2_11_18_1","unstructured":"Socialstyrelsen.Socialstyrelsen directory of national health registries.2025."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494821993723"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.14437"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5448587"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216311398300"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003529"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-024-02494-0"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7367"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.04.016"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.04.019"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.32408"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S327230"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2023.11.010"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.09.009"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad244"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.70601","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:21:25Z","timestamp":1790140885000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.70601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/codi.70601"],"URL":"https:\/\/doi.org\/10.1111\/codi.70601","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"assertion":[{"value":"2026-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70601"}}