{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:03:59Z","timestamp":1790143439101,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The randomized COLOPEC trial demonstrated no benefit of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in preventing peritoneal metastases in locally advanced colon cancer. Because all patients underwent a diagnostic laparoscopy at 18\u2009months, the study lacked a true control arm, leaving the effect of early detection and treatment compared with standard care uncertain. This study aimed to compare long\u2010term oncological outcomes between patients treated in the COLOPEC trial and patients treated in routine care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Patients who underwent curative resection for c\/pT4 or perforated colon cancer in the COLOPEC trial were compared with a retrospective control cohort that included all colon cancer resections performed in 2014\u20132015, in 50 Dutch hospitals. All 202 trial patients were matched 1:1 to 202 control patients using propensity score matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following treatment in both arms of the\n                      <jats:styled-content style=\"fixed-case\">COLOPEC<\/jats:styled-content>\n                      trial, compared to the matched control cohort, 5\u2010year overall survival was 70.2% versus 72.8% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.77). Five\u2010year disease\u2010free survival was 62.1% versus 65.2% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.31) and five\u2010year cumulative incidence of peritoneal metastases was 24.4% Versus 9.5% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cytoreductive surgery with\n                      <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content>\n                      for peritoneal recurrence was performed in 28 (13.9%) versus 7 patients (3.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite increased detection and more frequent treatment of peritoneal metastases in the COLOPEC trial, 5\u2010year overall and disease\u2010free survival were comparable to routine practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70614","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:28:57Z","timestamp":1789705737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection and treatment of peritoneal metastases in colon cancer:\n                    <scp>COLOPEC<\/scp>\n                    trial compared to routine practice"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0667-6791","authenticated-orcid":false,"given":"Iris","family":"Hochstenbach","sequence":"first","affiliation":[{"name":"Department of Surgery Isala  Zwolle the Netherlands"},{"name":"Department of Surgery University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8655-3275","authenticated-orcid":false,"given":"Julie J. M.","family":"Hamm","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-2550","authenticated-orcid":false,"given":"Eva","family":"Rademaker","sequence":"additional","affiliation":[{"name":"Department of Surgery Isala  Zwolle the Netherlands"},{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend G. J.","family":"Aalbers","sequence":"additional","affiliation":[{"name":"Department of Surgery Antoni van Leeuwenhoek Hospital\/the Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamila","family":"Boerma","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelmina M. U.","family":"van Grevenstein","sequence":"additional","affiliation":[{"name":"Department of Surgery University Medical Centre Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3228-6712","authenticated-orcid":false,"given":"Patrick H. J.","family":"Hemmer","sequence":"additional","affiliation":[{"name":"Department of Surgery University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignace H. J. T.","family":"De Hingh","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Catharina Cancer Institute, Catharina Hospital Eindhoven  Eindhoven the Netherlands"},{"name":"GROW\u2010School for Oncology and Developmental Biology Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1193-0214","authenticated-orcid":false,"given":"Niels F. M.","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Surgery Antoni van Leeuwenhoek Hospital\/the Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurriaan B.","family":"Tuynman","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam University Medical Centre  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8433-964X","authenticated-orcid":false,"given":"Eva V. E.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6773-9668","authenticated-orcid":false,"given":"Johannes H. W.","family":"de Wilt","sequence":"additional","affiliation":[{"name":"Department of Surgery Radboud University Medical Centre  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9447-8181","authenticated-orcid":false,"given":"Esther C. J.","family":"Consten","sequence":"additional","affiliation":[{"name":"Department of Surgery University Medical Centre Groningen  Groningen the Netherlands"},{"name":"Department of Surgery Meander Medical Centre  Amersfoort the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henderik L.","family":"van Westreenen","sequence":"additional","affiliation":[{"name":"Department of Surgery Isala  Zwolle the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-3310","authenticated-orcid":false,"given":"Pieter J.","family":"Tanis","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the COLOPEC Collaborators Group, Dutch Snapshot Research Group and Dutch Complex Colon Cancer 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