{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:59:36Z","timestamp":1790654376398,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Right\u2010sided colon cancer (RSCC) exhibits distinct characteristics, yet specific prognostic determinants remain insufficiently defined. This multicentre retrospective study evaluated clinicopathological and surgical factors influencing survival in a real\u2010world cohort undergoing curative resection for non\u2010metastatic RSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed 800 adults undergoing curative\u2010intent resection for non\u2010metastatic RSCC across 28 centres (2018\u20132024). The primary outcome was 3\u2010year overall survival (OS). Multivariate Cox model identified prognostic factors. An exploratory, post hoc subgroup analysis evaluated the impact of complete mesocolic excision (CME) on OS, stratified by tumour anatomical subsite.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age was 62.8\u2009years, and 24% required emergency surgery. CME was performed in 57.1% of patients, with baseline characteristics reflecting significant real\u2010world selection bias against CME in complex clinical presentations. At 3\u2009years (OS: 86%), multivariate analysis identified age (HR 1.071, 95% CI: 1.023\u20131.122,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and adjacent organ invasion (HR 3.642, 95% CI: 1.360\u20139.750,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) as independent mortality predictors. Unadjusted post hoc analysis suggested CME was associated with improved OS for ascending colon and hepatic flexure tumours (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although CME showed an exploratory site\u2010specific survival advantage, the critical lack of molecular profiling (MSI, RAS, BRAF) prevents adjustment for major biological confounders. Consequently, these findings are strictly hypothesis\u2010generating, highlighting real\u2010world surgical bias and require prospective multi\u2010institutional validation before altering standard practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70638","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:53:04Z","timestamp":1790653984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic factors of non\u2010metastatic right colon adenocarcinoma: A multicentre retrospective analysis from the\n                    <scp>ATCCR<\/scp>\n                    database"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9565-3562","authenticated-orcid":false,"given":"Salsabil","family":"Nasri","sequence":"first","affiliation":[{"name":"Department B of Surgery Charles Nicolle University Hospital of Tunis  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ali","family":"Chaouch","sequence":"additional","affiliation":[{"name":"Department of Visceral and Digestive Surgery Monastir University Hospital  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-239X","authenticated-orcid":false,"given":"Imen","family":"Mlouki","sequence":"additional","affiliation":[{"name":"Department of Preventive and Community Medicine, Mahdia University Hospital, Faculty of Medicine of Monastir University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4746-338X","authenticated-orcid":false,"given":"Mohamed Ben","family":"Hassine","sequence":"additional","affiliation":[{"name":"Department B of Surgery Charles Nicolle University Hospital of Tunis  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Bouchrika","sequence":"additional","affiliation":[{"name":"Department of Visceral and Digestive Surgery Monastir University Hospital  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9560-4445","authenticated-orcid":false,"given":"Amine Ben","family":"Safta","sequence":"additional","affiliation":[{"name":"Department B of Surgery Charles Nicolle University Hospital of Tunis  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2859-1901","authenticated-orcid":false,"given":"Aya Ajmi","family":"Blout","sequence":"additional","affiliation":[{"name":"Department of Preventive and Community Medicine, Mahdia University Hospital, Faculty of Medicine of Monastir University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8101-7563","authenticated-orcid":false,"given":"Emna","family":"Hariz","sequence":"additional","affiliation":[{"name":"Department of Preventive and Community Medicine, Mahdia University Hospital, Faculty of Medicine of Monastir University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3375-8400","authenticated-orcid":false,"given":"Sana","family":"El Mhamdi","sequence":"additional","affiliation":[{"name":"Department of Preventive and Community Medicine, Mahdia University Hospital, Faculty of Medicine of Monastir University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-1463","authenticated-orcid":false,"given":"Hiba Ben","family":"Hassine","sequence":"additional","affiliation":[{"name":"Department of Visceral and Digestive Surgery Monastir University Hospital  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Zouari","sequence":"additional","affiliation":[{"name":"Department of Visceral and Digestive Surgery Monastir University Hospital  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramzi","family":"Nouira","sequence":"additional","affiliation":[{"name":"Department B of Surgery Charles Nicolle University Hospital of Tunis  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"3","key":"e_1_2_14_2_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray F","year":"2024","journal-title":"CA Cancer J 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