{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:37:53Z","timestamp":1773283073104,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T00:00:00Z","timestamp":1348358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Time\u2010resolved spectroscopy (<jats:styled-content style=\"fixed-case\">TRS<\/jats:styled-content>\u201020) measures tissue oxygen saturation (%) by evaluating the absolute concentrations of oxygenated, deoxygenated and total haemoglobin based on measurement of the transit time of individual photons through a tissue of interest. We measured tissue oxygen saturation in the prefrontal lobes of the brain by <jats:styled-content style=\"fixed-case\">TRS<\/jats:styled-content>\u201020 in eighteen pregnant women during caesarean section. In a case of placenta previa, massive bleeding immediately decreased cerebral oxygen saturation from 67\u00b72% to 54\u00b72%, but did not alter peripheral tissue oxygenation as measured by pulse oximetry. Four cases of pre\u2010eclampsia revealed chronic changes in elevated base levels of cerebral oxygen saturation, though peripheral oxygen saturation was similar to that in normotensive pregnant women. Average cerebral oxygen saturation in the cases of pre\u2010eclampsia before the introduction of anaesthesia was 73\u00b76\u00a0\u00b1\u00a04\u00b74 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>)% (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), significantly higher than in normotensive pregnant women, 67\u00b72\u00a0\u00b1\u00a04\u00b73% (<jats:italic>n<\/jats:italic>\u00a0=\u00a013, <jats:italic>P<\/jats:italic>&lt;0\u00b705). <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>\u2010scores of cerebral oxygen saturation prior to anaesthesia positively correlated with those of systolic or diastolic blood pressure. <jats:styled-content style=\"fixed-case\">TRS<\/jats:styled-content>\u201020 could detect acute as well as chronic changes in brain oxygen saturation in response to pregnancy\u2010associated complications.<\/jats:p>","DOI":"10.1111\/cpf.12001","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T02:43:19Z","timestamp":1348454599000},"page":"109-116","source":"Crossref","is-referenced-by-count":13,"title":["Cerebral oxygen saturation evaluated by near\u2010infrared time\u2010resolved spectroscopy (<scp>TRS<\/scp>) in pregnant women during caesarean section \u2013 a promising new method of maternal monitoring"],"prefix":"10.1111","volume":"33","author":[{"given":"Kaori","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunao","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotomi","family":"Nagahashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoaki","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Maeda","sequence":"additional","affiliation":[{"name":"Hamamatsu Photonics K.K. 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