{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:25:57Z","timestamp":1697693157735},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the long\u2010term prognostic value of various types of perfusion defects detected by single\u2010photon emission computed tomography (<jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>) in patients with stable angina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven hundred and thirty two patients (299 men, mean age 57\u00a0\u00b1\u00a09\u00a0years) with suspected or known stable coronary artery disease underwent rest\/exercise <jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content> protocol using 99mTc\u2010methoxyisobutylisonitrile (<jats:styled-content style=\"fixed-case\">MIBI<\/jats:styled-content>). All patients completed clinical follow\u2010up regarding cardiac events (cardiac death, sudden cardiac death, acute coronary syndrome, revascularization, cardiac hospitalization) for a mean period of 58\u00a0\u00b1\u00a08\u00a0months. Event rates were analysed in subgroups defined according to the presence of fixed or inducible myocardial perfusion defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the follow\u2010up, 15 cardiac deaths were recorded, 13 of which were qualified as a sudden cardiac death, 59 acute coronary syndromes, 65 revascularizations and 209 cardiac hospitalizations. The presence of inducible perfusion defects on <jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content> was associated with a high risk for occurrence of all analysed end points: sudden cardiac death (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a03\u00b796, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701), cardiac hospitalization (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01\u00b75, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004), coronary syndrome (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a02\u00b733, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001) and coronary revascularization (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a02\u00b776, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70002), except for the cardiac death (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b727). Resting perfusion defects were highly predictive for cardiac death (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a07\u00b745; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001), but not for other cardiac events (<jats:italic>P\u00a0<\/jats:italic>=\u00a0<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). The presence of any (inducible or resting) perfusion defects was associated with a high risk of all cardiovascular complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In long\u2010term follow\u2010up, <jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content> proved highly predictive of cardiac events in patients with suspected or known <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>. In the revascularization era, cardiac death is most accurately related to the presence of resting perfusion defects, but all other cardiac events were better predicted by inducible perfusion defects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12016","type":"journal-article","created":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T09:02:47Z","timestamp":1357117367000},"page":"218-223","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term prognostic value of inducible and resting perfusion defects detected by single\u2010photon emission computed tomography in the era of wide availability of coronary revascularization"],"prefix":"10.1111","volume":"33","author":[{"given":"Dominika","family":"Filipiak\u2010Strzecka","sequence":"first","affiliation":[{"name":"Department of Cardiology Bieganski Hospital, Medical University of Lodz Lodz 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