{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T21:54:48Z","timestamp":1764194088628},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The objective of this cross\u2010sectional study was to analyse the acute effect of aquatic exercise on haemostasis in persons with haemophilia. Ten adult haemophiliacs (8 type A, 2 type B) familiarized with aquatic training performed a 20\u2010min exercise session in a swimming pool at an intensity of ~70% maximum heart rate (HR). Blood samples were collected immediately after the training session. The haemostatic parameters selected for analyses were factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content>), prothrombin time (<jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>), activated partial thromboplastin time (<jats:styled-content style=\"fixed-case\">APTT<\/jats:styled-content>) and fibrinogen. There were unclear effects of the exercise bout on <jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">APTT<\/jats:styled-content>, with a possibly beneficial effect on <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> (\u221211\u00b74%; 90% confidence interval: \u221226\u00b71;3\u00b73%), and a trivial change on fibrinogen levels. It was found an association between the mean rise in <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> during exercise and the decrement in <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> after exercise (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b7729; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7026). The greater changes were observed in the patients diagnosed with a moderate level of haemophilia. It is concluded that a short bout of moderate intensity of aquatic exercise may have a positive influence on <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> in adults with haemophilia with greater changes in those individuals exhibiting a greater rise in <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> during exercise. This may be an important issue to the haemostatic control of haemophiliacs in clinical settings. Further studies are warranted for testing the influence of different aquatic exercise intensities on haemostasis.<\/jats:p>","DOI":"10.1111\/cpf.12145","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T01:29:37Z","timestamp":1397179777000},"page":"191-196","source":"Crossref","is-referenced-by-count":7,"title":["The acute effect of moderate intensity aquatic exercise on coagulation factors in haemophiliacs"],"prefix":"10.1111","volume":"35","author":[{"given":"Luis Gustavo Normanton","family":"Beltrame","sequence":"first","affiliation":[{"name":"Post\u2010Graduate Program In Physical Education Catholic University of Bras\u00edlia, \u00c1guas Claras Bras\u00edlia Brazil"},{"name":"International Hemophilia Training Center (IHTC) Bras\u00edlia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurinda","family":"Abreu","sequence":"additional","affiliation":[{"name":"Independent Researcher Lavadores Vigo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussara","family":"Almeida","sequence":"additional","affiliation":[{"name":"International Hemophilia Training Center (IHTC) Bras\u00edlia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Alexandre","family":"Boullosa","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Program In Physical Education Catholic University of Bras\u00edlia, \u00c1guas Claras Bras\u00edlia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1152\/jappl.1986.60.6.1917","article-title":"Increases in factor VIII complex and fibrinolytic activity are dependent on exercise intensity","volume":"60","author":"Andrew M","year":"1986","journal-title":"J Appl Physiol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(90)90262-B"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.440532.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2326-6-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.40.3.287"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1024748"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199512000-00009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200005000-00007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1152\/jappl.1987.62.4.1416","article-title":"Effects of exercise and conditioning on clotting and fibrinolytic activity in men","volume":"62","author":"Ferguson EW","year":"1987","journal-title":"J Appl Physiol"},{"issue":"2","key":"e_1_2_7_11_1","first-page":"103","article-title":"Analysis of the effects of aquatics rehabilitation in static postural control in patients hemophiliac: case study","volume":"12","author":"Franco J","year":"2006","journal-title":"Haemophilia"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01354.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01860.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1152\/jappl.1992.73.6.2499","article-title":"Increased thrombin\u2010antithrombin III complexes after 1\u00a0h of physical exercise","volume":"73","author":"Herren T","year":"1992","journal-title":"J Appl Physiol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31818cb278"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19780152"},{"key":"e_1_2_7_17_1","volume-title":"Genetics of hemophilia A and B: An introduction for clinicians","author":"Kasper CK","year":"2007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830160304"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1973.tb10541.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e318295d534"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1222605"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-0038-1650010","article-title":"Marathon run III: effects on coagulation, fibrinolysis, platelet aggregation and serum cortisol levels. 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