{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T13:59:28Z","timestamp":1715608768706},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Transcatheter aortic valve implantation (<jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content>) is an established method for the treatment of high\u2010risk patients with aortic stenosis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>). The beneficial effects of <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> in cardiac hemodynamics have been described in recent studies, but those investigations were mostly performed after an interval of more than 6\u00a0months following aortic valve implantation. The aim of this study is to investigate the acute and short\u2010term alterations in hemodynamic conditions using the echocardiography outcomes in patients undergoing <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A total of 60 patients (26 males, 34 females; age 84\u00b77\u00a0\u00b1\u00a05\u00b78) who underwent <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> with CoreValve system were included in the study. Echocardiography was performed before hospital discharge and at 3\u00a0months follow\u2010up. As expected, <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> was associated with an immediate significant improvement in aortic valve area (<jats:styled-content style=\"fixed-case\">AVA<\/jats:styled-content>) (from 0\u00b764\u00a0\u00b1\u00a00\u00b716\u00a0cm<jats:sup>2<\/jats:sup> to 1\u00b767\u00a0\u00b1\u00a00\u00b741\u00a0cm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2010value&lt;0\u00b7001) and mean gradient (from 51\u00b79\u00a0\u00b1\u00a015\u00b74\u00a0mmHg to 8\u00b78\u00a0\u00b1\u00a03\u00b78\u00a0mmHg, <jats:italic>P<\/jats:italic>\u2010value&lt;0\u00b7001). At 3\u2010month follow\u2010up, systolic <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> function was augmented (<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>: 50\u00a0\u00b1\u00a014% to 54\u00a0\u00b1\u00a011%, <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00\u00b7024). Left ventricle (LV) mass and left atrium (LA) volume were significantly reduced (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mass index from 126\u00b75\u00a0\u00b1\u00a030\u00b75\u00a0g\u00a0m<jats:sup>\u22122<\/jats:sup> to 102\u00b74\u00a0\u00b1\u00a032\u00b74\u00a0g\u00a0m<jats:sup>\u22122<\/jats:sup>; <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> index from 42\u00b79\u00a0\u00b1\u00a017\u00b73\u00a0ml\u00a0m<jats:sup>\u22122<\/jats:sup> to 33\u00b76\u00a0\u00b1\u00a010\u00b76\u00a0ml\u00a0m<jats:sup>\u22122<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2010value&lt;0\u00b7001 for both). Furthermore, a decrement in systolic pulmonary artery pressure (<jats:styled-content style=\"fixed-case\">SPAP<\/jats:styled-content>) from 47\u00b75\u00a0\u00b1\u00a013\u00b75\u00a0mmHg to 42\u00b75\u00a0\u00b1\u00a011\u00b72\u00a0mmHg, <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00\u00b702 was also observed. Despite the high incidence of paravalvular regurgitation (<jats:styled-content style=\"fixed-case\">PVR<\/jats:styled-content>) (80%), most of the patients presented mild or trace <jats:styled-content style=\"fixed-case\">PVR<\/jats:styled-content> and no significant progress of the regurgitation grade was seen after 3\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that the beneficial effects of <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> in cardiac function and hemodynamics occur already after a short period following aortic valve implantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12153","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T02:02:50Z","timestamp":1398218570000},"page":"216-222","source":"Crossref","is-referenced-by-count":1,"title":["Hemodynamic outcomes of transcatheter aortic valve implantation with the CoreValve system: an early 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