{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:52:15Z","timestamp":1788871935114,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"The Swedish Heart-Lung Foundation","award":["2012-02-09"],"award-info":[{"award-number":["2012-02-09"]}]},{"DOI":"10.13039\/501100001862","name":"The Swedish Research Council","doi-asserted-by":"crossref","award":["2011-3579"],"award-info":[{"award-number":["2011-3579"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Summary<\/jats:title>\n \n Introduction<\/jats:title>\n \n Left ventricular (\n LV<\/jats:styled-content>\n ) hypertrophy (\n LVH<\/jats:styled-content>\n ) and reduced\n LV<\/jats:styled-content>\n function correlate with poor prognosis in patients with chronic kidney disease (\n CKD<\/jats:styled-content>\n ). Our aim is to investigate whether mild\u2010to\u2010moderate\n CKD<\/jats:styled-content>\n is associated with cardiac abnormalities.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Echocardiography, including tissue Doppler imaging, was performed in 103 patients with\n CKD<\/jats:styled-content>\n at stages 2\u20133 and 4\u20135, and in 53 healthy controls. The systolic (\n s<\/jats:italic>\n \u2032) and diastolic myocardial velocity (\n e<\/jats:italic>\n \u2032), and the transmitral diastolic flow velocity (\n E<\/jats:italic>\n ) were measured, and\n E<\/jats:italic>\n \/\n e<\/jats:italic>\n \u2032 was calculated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients with chronic kidney disease had higher mean\n E<\/jats:italic>\n \/\n e<\/jats:italic>\n \u2032 than controls (mean\n E<\/jats:italic>\n \/\n e<\/jats:italic>\n \u2032: controls 5\u00b700\u00a0\u00b1\u00a01\u00b723 versus\n CKD<\/jats:styled-content>\n 4\u20135 6\u00b736\u00a0\u00b1\u00a01\u00b771,\n P<\/jats:italic>\n <0\u00b7001 and versus\n CKD<\/jats:styled-content>\n 2\u20133 5\u00b769\u00a0\u00b1\u00a01\u00b747,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0\u00b705), indicating altered diastolic function in the patients. The\n CKD<\/jats:styled-content>\n groups showed lower longitudinal systolic function than controls, as assessed by atrio\u2010ventricular plane displacement and\n s<\/jats:italic>\n \u2032 (mean\n s<\/jats:italic>\n \u2032: controls 11\u00b75\u00a0\u00b1\u00a01\u00b79\u00a0cm\u00a0s\n \u22121<\/jats:sup>\n versus\n CKD<\/jats:styled-content>\n 4\u20135 10\u00b74\u00a0\u00b1\u00a02\u00b71\u00a0cm\u00a0s\n \u22121<\/jats:sup>\n ,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0\u00b703 and versus\n CKD<\/jats:styled-content>\n 2\u20133 10\u00b74\u00a0\u00b1\u00a02\u00b71\u00a0cm\u00a0s\n \u22121<\/jats:sup>\n ,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0\u00b702). The prevalence of\n LVH<\/jats:styled-content>\n was higher in patients with\n CKD<\/jats:styled-content>\n than in controls (controls 13% versus\n CKD<\/jats:styled-content>\n 4\u20135 37%,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0\u00b7006 and versus\n CKD<\/jats:styled-content>\n 2\u20133 30%,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0\u00b703).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Alterations in systolic and diastolic myocardial function can be seen in mild\u2010to\u2010moderate\n CKD<\/jats:styled-content>\n compared with controls, indicating that cardiac involvement starts early in\n CKD<\/jats:styled-content>\n , which may be a precursor of premature cardiac morbidity.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cpf.12154","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T05:38:39Z","timestamp":1398058719000},"page":"223-230","source":"Crossref","is-referenced-by-count":20,"title":["Cardiac remodelling and functional alterations in mild\u2010to\u2010moderate renal dysfunction: comparison with healthy subjects"],"prefix":"10.1111","volume":"35","author":[{"given":"Anna M.","family":"Asp","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin","family":"Wallquist","sequence":"additional","affiliation":[{"name":"Department of Nephrology Karolinska University Hospital Karolinska Institutet Stockholm Sweden"},{"name":"Division of Nephrology Department of Medicine V\u00e4stmanlands Hospital 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