{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:28:44Z","timestamp":1776706124483,"version":"3.51.2"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulse pressure variation (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>) is a dynamic index of fluid responsiveness. This parameter helps clinicians in improving haemodynamic status while avoiding potential fluid overload. Echocardiographic indices, such as E\/E' ratio and left atrial (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>) strain by speckle tracking echocardiography (<jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>), are used to estimate left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) filling pressures. This study aimed at exploring the relationship between <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> and echocardiographic indices of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> filling pressures in critically ill patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010two patients (mean age of 50\u00b79\u00a0\u00b1\u00a021\u00b76, male\/female = 15\/7) admitted to intensive care unit, and requiring mechanical ventilation and invasive arterial pressure monitoring, were studied. In all patients, two independent operators assessed simultaneously <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>, using a pulse contour method, mean E\/E' ratio and peak atrial longitudinal strain (<jats:styled-content style=\"fixed-case\">PALS<\/jats:styled-content>) by means of <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PALS<\/jats:styled-content> values were obtained by averaging <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> segments measured in the 4\u2010chamber and 2\u2010chamber views (global <jats:styled-content style=\"fixed-case\">PALS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant negative correlation was found between mean E\/E' ratio and <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a0\u22120\u00b776; <jats:italic>P<\/jats:italic>&lt;0\u00b7001). A positive correlation between global <jats:styled-content style=\"fixed-case\">PALS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> was found (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00\u00b780, <jats:italic>P<\/jats:italic>&lt;0\u00b7001). Mean global <jats:styled-content style=\"fixed-case\">PALS<\/jats:styled-content> of 26\u00b72% demonstrated excellent accuracy (Area Under Roc Curve = 0\u00b786, <jats:italic>P<\/jats:italic>&lt;0\u00b7001), and good sensitivity (92%) and specificity (86%) in predicting a <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> &gt;15%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a group of mechanically ventilated patients <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>, derived from pulse contour analysis, and echocardiographic preload parameters were well correlated. Global <jats:styled-content style=\"fixed-case\">PALS<\/jats:styled-content> by <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> provided better estimation of <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> than mean E\/E' ratio. <jats:styled-content style=\"fixed-case\">PALS<\/jats:styled-content> seems a potential alternative to <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> in assessing fluid responsiveness in critically ill patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12168","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T02:17:05Z","timestamp":1402021025000},"page":"344-350","source":"Crossref","is-referenced-by-count":8,"title":["Relationship between pulse pressure variation and echocardiographic indices of left ventricular filling pressure in critically ill patients"],"prefix":"10.1111","volume":"35","author":[{"given":"Matteo","family":"Cameli","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena Italy"},{"name":"Unit of Cardiovascular Diseases University of Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Bigio","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena Italy"},{"name":"Unit of Anesthesia and Intensive Care Unit University of Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Lisi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena Italy"},{"name":"Unit of Cardiovascular Diseases University of Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca M.","family":"Righini","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies 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