{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:17:34Z","timestamp":1696403854648},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) torsion is an important parameter of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> performance and can be influenced by several factors. Aim of this investigation was to evaluate whether <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> prolongation in left bundle branch block (<jats:styled-content style=\"fixed-case\">LBBB<\/jats:styled-content>) may influence global <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> twist and twisting\/untwisting rate in chronic systolic heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively evaluated 30 healthy subjects (control group) and 100 chronic <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> patients with severely impaired <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> systolic function (ejection fraction \u226435%). Patients were divided into three groups according to <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> duration: <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> QRS<\/jats:styled-content>\u00a0&lt;\u00a0120\u00a0ms (<jats:italic>n<\/jats:italic> 49), <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>: 120\u00a0\u2264\u00a0<jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\u00a0\u2264\u00a0150\u00a0ms (<jats:italic>n<\/jats:italic> 28) and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> QRS<\/jats:styled-content>\u00a0&gt;\u00a0150\u00a0ms (<jats:italic>n<\/jats:italic> 23). Patients in groups <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> presented <jats:styled-content style=\"fixed-case\">LBBB<\/jats:styled-content>. All subjects underwent standard trans\u2010thoracic echocardiography and two\u2010dimensional speckle\u2010tracking echocardiography evaluation. Categorical variables were compared by the chi\u2010square or the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>isher's exact test. Continuous variables were compared using the <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content> test. Correlations between variables were analysed with linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Control subjects presented higher torsion parameters, when compared with patients in any <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> group. Among the three <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> groups, no differences were detected in global twist (4\u00b779\u00a0\u00b1\u00a03\u00b754, 3\u00b78\u00a0\u00b1\u00a03\u00b70 and 4\u00b715\u00a0\u00b1\u00a03\u00b714 degrees, respectively), twist rate max (44\u00b781\u00a0\u00b1\u00a025\u00b703, 37\u00b794\u00a0\u00b1\u00a019\u00b709 and 37\u00b761\u00a0\u00b1\u00a024\u00b749\u00a0degrees\u00a0s<jats:sup>\u22121<\/jats:sup>, respectively) and untwist rate max (\u221236\u00b731\u00a0\u00b1\u00a030\u00b789, \u221227\u00b768\u00a0\u00b1\u00a034\u00b767 and \u221239\u00b762\u00a0\u00b1\u00a026\u00b727\u00a0degrees\u00a0s<jats:sup>\u22121<\/jats:sup>, respectively) (<jats:italic>P<\/jats:italic>&gt;0\u00b705 for all). At linear regression analysis, there was no relation between <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> duration and any torsion parameter (<jats:italic>P<\/jats:italic>&gt;0\u00b705 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with chronic severe systolic heart failure, <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> duration and <jats:styled-content style=\"fixed-case\">LBBB<\/jats:styled-content> morphology do not affect <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> twisting and untwisting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12181","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T08:07:50Z","timestamp":1406794070000},"page":"436-442","source":"Crossref","is-referenced-by-count":0,"title":["<scp>QRS<\/scp> duration in left bundle branch block does not affect left ventricular twisting in chronic systolic heart 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