{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:38:34Z","timestamp":1792463914758,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The ventilatory anaerobic threshold (<jats:styled-content style=\"fixed-case\">VAT<\/jats:styled-content>) is an important method to assess the aerobic fitness in patients with cardiopulmonary disease. Several methods exist to determine the <jats:styled-content style=\"fixed-case\">VAT<\/jats:styled-content>; however, there is no consensus which of these methods is the most accurate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare four different non\u2010invasive methods for the determination of the <jats:styled-content style=\"fixed-case\">VAT<\/jats:styled-content> via respiratory gas exchange analysis during a cardiopulmonary exercise test (<jats:styled-content style=\"fixed-case\">CPET<\/jats:styled-content>). A secondary objective is to determine the interobserver reliability of the <jats:styled-content style=\"fixed-case\">VAT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CPET<\/jats:styled-content> data of 30 children diagnosed with either cystic fibrosis (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>;<jats:italic> N<\/jats:italic>\u00a0=\u00a015) or with a surgically corrected dextro\u2010transposition of the great arteries (aso<jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>;<jats:italic> N<\/jats:italic>\u00a0=\u00a015) were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were found between conditions or among testers. The <jats:styled-content style=\"fixed-case\">RER<\/jats:styled-content>\u00a0=\u00a01 method differed the most compared to the other methods, showing significant higher results in all six variables. The <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content><jats:sub>2<\/jats:sub> method differed significantly on five of six and four of six exercise variables with the <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>\u2010slope method and the <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>ent<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>q method, respectively. The <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>\u2010slope and the <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>ent<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>q method differed significantly on one of six exercise variables. Ten of thirteen <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>s that were &gt;0\u00b780 had a 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0&gt;\u00a00\u00b770. The <jats:styled-content style=\"fixed-case\">RER<\/jats:styled-content>\u00a0=\u00a01 method and the <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>\u2010slope method had the highest number of significant <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>s and 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>\u2010slope method, the ventilatory equivalent method and the <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content><jats:sub>2<\/jats:sub> method are comparable and reliable methods to determine the <jats:styled-content style=\"fixed-case\">VAT<\/jats:styled-content> during <jats:styled-content style=\"fixed-case\">CPET<\/jats:styled-content> in children with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> or aso<jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12183","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T08:08:03Z","timestamp":1406794083000},"page":"451-459","source":"Crossref","is-referenced-by-count":8,"title":["Comparing four non\u2010invasive methods to determine the ventilatory anaerobic threshold during cardiopulmonary exercise testing in children with congenital heart or lung disease"],"prefix":"10.1111","volume":"35","author":[{"given":"Naomi. 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