{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:29Z","timestamp":1787014049448,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The identification of the vulnerable atheroma plaque could allow a more effective treatment of cerebrovascular accident (\n                      <jats:styled-content style=\"fixed-case\">CVA<\/jats:styled-content>\n                      ). Active calcification and inflammation of the carotid atheroma were assessed and compared in symptomatic and asymptomatic plaques by 18F\u2010NaF and 18F\u2010\n                      <jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Nine patients investigated for recent\n                      <jats:styled-content style=\"fixed-case\">CVA<\/jats:styled-content>\n                      and no preventive treatment with statins were enrolled. In each patient, at least one atheroma plaque was detected by\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      angiogram. In total, 18 plaques were available: 9 symptomatic and 9 asymptomatic. 18F\u2010NaF uptake and 18F\u2010\n                      <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\n                      uptake by each plaque were assessed visually and semiquantitatively by calculating target\/background ratios (\n                      <jats:styled-content style=\"fixed-case\">TBR<\/jats:styled-content>\n                      s) and\n                      <jats:styled-content style=\"fixed-case\">TBR<\/jats:styled-content>\n                      indexes (\n                      <jats:styled-content style=\"fixed-case\">TBR<\/jats:styled-content>\n                      symptomatic\/\n                      <jats:styled-content style=\"fixed-case\">TBR<\/jats:styled-content>\n                      asymptomatic and 18F\u2010NaF\n                      <jats:styled-content style=\"fixed-case\">TBR<\/jats:styled-content>\n                      \/18F\u2010\n                      <jats:styled-content style=\"fixed-case\">FDG TBR<\/jats:styled-content>\n                      within each of the 2 clinical groups of plaques).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All plaques showed 18F\u2010NaF and 18F\u2010\n                      <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\n                      uptake, and semiquantitation showed higher 18F\u2010NaF uptake by 11 of the 18 plaques, 6 symptomatic and 5 asymptomatic. In the symptomatic group, the mean 18F\u2010NaF\n                      <jats:styled-content style=\"fixed-case\">TBR<\/jats:styled-content>\n                      was 2\u00b712\u00a0\u00b1\u00a00\u00b744, and in the asymptomatic group, it was 1\u00b785\u00a0\u00b1\u00a00\u00b746. The 18F\u2010NaF\/18F\u2010\n                      <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\n                      showed that, overall, 18F\u2010NaF uptake is higher than 18F\u2010\n                      <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\n                      . In the symptomatic plaques, the 18F\u2010NaF was higher for the low calcium content and the lowest for the high.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Active calcification and inflammation are simultaneous processes in the symptomatic and asymptomatic carotid atheroma. However, active calcification seems predominant over inflammation in both groups. In the symptomatic plaques, the highest 18F\u2010NaF uptake does not correspond with the largest calcium content. These patterns open new insights on the role of 18F\u2010NaF in the study of calcification and in the identification of the vulnerable carotid atheroma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cpf.12254","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T14:28:14Z","timestamp":1435933694000},"page":"499-503","source":"Crossref","is-referenced-by-count":38,"title":["New insight of functional molecular imaging into the atheroma biology: 18F\u2010NaF and 18F\u2010\n                    <scp>FDG<\/scp>\n                    in symptomatic and asymptomatic carotid plaques after recent\n                    <scp>CVA<\/scp>\n                    . Preliminary results"],"prefix":"10.1111","volume":"36","author":[{"given":"R.","family":"Quirce","sequence":"first","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Service University Hospital \u201cMarqu\u00e9s de Valdecilla\u201d University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Mart\u00ednez\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Service University Hospital \u201cMarqu\u00e9s de Valdecilla\u201d University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Banzo","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Service University Hospital \u201cMarqu\u00e9s de Valdecilla\u201d University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jim\u00e9nez\u2010Bonilla","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Service University Hospital \u201cMarqu\u00e9s de Valdecilla\u201d University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Mart\u00ednez\u2010Amador","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Service University Hospital \u201cMarqu\u00e9s de Valdecilla\u201d University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ib\u00e1\u00f1ez\u2010Bravo","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Service University Hospital \u201cMarqu\u00e9s de Valdecilla\u201d University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"L\u00f3pez\u2010Defill\u00f3","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Service University Hospital \u201cMarqu\u00e9s de Valdecilla\u201d University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jim\u00e9nez\u2010Alonso","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Service University Hospital \u201cMarqu\u00e9s de Valdecilla\u201d University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Revilla","sequence":"additional","affiliation":[{"name":"Neurology Service University Hospital \u201cMarqu\u00e9s de Valdecilla\u201d IDIVAL Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Carril","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging Service University Hospital \u201cMarqu\u00e9s de Valdecilla\u201d University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.732867"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-013-0364-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001534"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-012-9631-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.076471"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.051052"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.037"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61754-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200107000-00004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.052233"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00036.2012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.234146"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12105"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3182816280"},{"key":"e_1_2_6_17_1","first-page":"22","article-title":"Contribution of 18F\u2010sodium fluoride PET\/CT to the study of the carotid atheroma calcification","volume":"32","author":"Quirce R","year":"2013","journal-title":"Rev Esp Med Nucl Imagen Mol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.065151"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000020548.60110.76"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.05.076"},{"key":"e_1_2_6_21_1","first-page":"38","article-title":"Imaging atherosclerotic macrophage density by positron emission tomography using F\u201018 fluorodeoxyglucose (FDG)","volume":"37","author":"Vallabhajosula S","year":"1996","journal-title":"J Nucl Med"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606310103"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1994-7"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcpf.12254","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.12254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T22:00:45Z","timestamp":1696370445000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpf.12254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,3]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/cpf.12254"],"URL":"https:\/\/doi.org\/10.1111\/cpf.12254","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"value":"1475-0961","type":"print"},{"value":"1475-097X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,3]]}}}