{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T06:02:22Z","timestamp":1789365742537,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009584","name":"Toyota Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Previous studies have demonstrated that dynamic cerebral autoregulation to spontaneous fluctuations in blood pressure is enhanced following lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>) infusion, a human experimental model of early sepsis, whereas by contrast it is impaired in patients with severe sepsis or septic shock. In this study, we hypothesized that this pattern of response would be identical during induced changes in blood pressure. Dynamic cerebral autoregulation was assessed in nine healthy volunteers and six septic patients. The healthy volunteers underwent a 4\u2010h intravenous infusion of <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> (total dose: 2\u00a0ng\u00a0kg<jats:sup>\u22121<\/jats:sup>). Mean arterial blood pressure (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>, arterial transducer) and middle cerebral artery blood flow velocity (<jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>v, transcranial Doppler ultrasound) were recorded continuously during thigh\u2010cuff deflation\u2010induced changes in <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> for the determination of a modified rate of regulation (RoR). This was performed before and after <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> infusion in healthy volunteers, and within 72\u00a0h following clinical diagnosis of sepsis in patients. In healthy volunteers, thigh\u2010cuff deflation caused a <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> reduction of 16 (13\u201320) % at baseline and 18 (16\u201320) % after <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>, while the <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> reduction was 12 (11\u201313) % in patients (<jats:italic>P<\/jats:italic>&lt;0\u00b705 versus volunteers at baseline; <jats:italic>P<\/jats:italic>&lt;0\u00b701 versus volunteers after <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>). The corresponding RoR values increased from 0\u00b746 (0\u00b731\u20130\u00b749) s<jats:sup>\u22121<\/jats:sup> at baseline to 0\u00b758 (0\u00b736\u20130\u00b774) s<jats:sup>\u22121<\/jats:sup> after <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>&lt;0\u00b705) in healthy volunteers, whereas they were similar to values observed in patients [0\u00b743 (0\u00b736\u20130\u00b752) s<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b791 versus baseline; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b714 versus <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>]. While our findings support the concept that dynamic cerebral autoregulation is enhanced during the very early stages of sepsis, they remain inconclusive with regard to more advanced stages of disease, because thigh\u2010cuff deflation failed to induce sufficient <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> reductions in patients.<\/jats:p>","DOI":"10.1111\/cpf.12256","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T12:45:55Z","timestamp":1432817155000},"page":"490-496","source":"Crossref","is-referenced-by-count":14,"title":["Dynamic cerebral autoregulation to induced blood pressure changes in human experimental and clinical sepsis"],"prefix":"10.1111","volume":"36","author":[{"given":"Ronan M. 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