{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:44:53Z","timestamp":1791492293333,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T00:00:00Z","timestamp":1435968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In bone scan patients with dialysis\u2010treated chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) and hyperparathyroidism, soft tissue accumulation of technetium\u201099\u00a0m hydroxy\/methylene diphosphonate (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>c\u201099\u00a0m\u2010<jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MDP<\/jats:styled-content>) has been reported primarily in case reports and usually explained by hypercalcaemia and\/or hyperphosphataemia. As human vascular smooth muscle cells produce hydroxyapatite during cell culture with increased phosphate levels and as <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>c\u201099\u00a0m\u2010<jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MDP<\/jats:styled-content> primarily binds to hydroxyapatite, we hypothesized that soft tissue accumulation would be found in patients with hyperphosphataemia. We identified 63 <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> patients diagnosed with secondary hyperparathyroidism admitted for <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>c\u201099\u00a0m\u2010<jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content> bone scan. Baseline characteristics and mean concentrations of biochemical markers (including <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010calcium and <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010phosphate) taken 0\u20133\u00a0months prior to the bone scans were collected. Soft tissue uptake was detected on bone scans in 37 of 63 (59%) patients. Primary locations were in the heart (27\/37\u00a0=\u00a073%), muscles (12\/37\u00a0=\u00a032%), lung (9\/37\u00a0=\u00a024%) and gastrointestinal tract (6\/37\u00a0=\u00a016%), and 13 of 37 (35%) patients had simultaneous uptake in more than one location. Regarding biochemical markers, patients with soft tissue uptake only differed from patients without in terms of plasma phosphate levels (1\u00b795\u00a0\u00b1\u00a00\u00b715 (<jats:italic>n<\/jats:italic>\u00a0=\u00a037) versus 1\u00b727\u00a0\u00b1\u00a00\u00b708 (<jats:italic>n<\/jats:italic>\u00a0=\u00a026), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70012). All patients with myocardial uptake (<jats:italic>n<\/jats:italic>\u00a0=\u00a027) had a coronary arteriography\u2010verified history of coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>), whereas <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> was only present in six of the 36 patients without myocardial uptake. In conclusion, dialysis\u2010treated <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> patients with secondary hyperparathyroidism have a high incidence of soft tissue uptake, and this finding is strongly correlated with elevated phosphate, but not calcium values.<\/jats:p>","DOI":"10.1111\/cpf.12276","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T06:38:38Z","timestamp":1435991918000},"page":"131-136","source":"Crossref","is-referenced-by-count":9,"title":["Increased technetium\u201099\u00a0m hydroxy diphosphonate soft tissue uptake on bone scintigraphy in chronic kidney disease patients with secondary hyperparathyroidism: correlation with hyperphosphataemia"],"prefix":"10.1111","volume":"37","author":[{"given":"Lotte Hahn","family":"Enevoldsen","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine and PET Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Heaf","sequence":"additional","affiliation":[{"name":"Department of Nephrology Herlev Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liselotte","family":"H\u00f8jgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine and PET Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zerahn","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Herlev Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hasbak","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine and PET Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70302-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v31.pm9531176"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000133041.27682.A2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5603\/NMR.2013.0040"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.RLU.0000067505.24908.5C"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00434.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.12.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP59059"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12102131"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2013.871250"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90352-8"},{"key":"e_1_2_6_14_1","first-page":"H341","article-title":"Bone extraction and blood clearance of diphosphonate in the dog","volume":"232","author":"Hughes SP","year":"1977","journal-title":"Am J Physiol"},{"key":"e_1_2_6_15_1","first-page":"469","article-title":"Reversible extraskeletal uptake of bone scanning in primary hyperparathyroidism","volume":"37","author":"Hwang GJ","year":"1996","journal-title":"J Nucl Med"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199401000-00004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.7.e10"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1673.2001.00989.x"},{"key":"e_1_2_6_19_1","first-page":"S1","volume":"113","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKDMBD Work Group. 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