{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:19:42Z","timestamp":1760955582953},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The sympathetic nervous system is affected in patients with chronic renal failure (<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>). This study tested the hypothesis that patients with <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> have an altered skeletal muscle metaboreflex. Twenty patients with <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> and 18 healthy subjects of similar age participated in the study. The muscle metaboreflex was determined based on heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>), mean arterial pressure, calf blood flow and calf vascular resistance (<jats:styled-content style=\"fixed-case\">CVR<\/jats:styled-content>) in response to handgrip exercise. The control of vascular resistance in the calf muscle mediated by the metaboreflex was estimated by subtracting the area under the curve with circulatory occlusion from that without occlusion. Arterial pressure and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> responses during exercise and recovery were similar in two groups of subjects. In the control group, <jats:styled-content style=\"fixed-case\">CVR<\/jats:styled-content> increased during exercise and remained elevated during circulatory occlusion, whereas no significant change was seen in the patients. Thus, the index of the metaboreflex was 7\u00b782\u00a0\u00b1\u00a09\u00b757 in the patients versus16\u00b752\u00a0\u00b1\u00a014 units in the controls. The findings demonstrate that patients with CRF have a decreased vascular resistance response in the calf during the handgrip exercise, which suggests that <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> condition attenuates this reflex.<\/jats:p>","DOI":"10.1111\/cpf.12293","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T02:19:33Z","timestamp":1440469173000},"page":"229-234","source":"Crossref","is-referenced-by-count":2,"title":["Skeletal muscle metaboreflex in patients with chronic renal failure"],"prefix":"10.1111","volume":"37","author":[{"given":"Paulo J. 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