{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:14:13Z","timestamp":1696317253173},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Knowledge of factors influencing the heterogeneity of blood transit times is important in cardiovascular physiology. The aim of the study was to investigate the effect of beta\u2010adrenergic blockade on blood transit time dispersion in awake, anxious volunteers. Recirculatory modelling of the disposition of intravascular markers using parametric forms for transit time distributions, such as the inverse <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>aussian distribution, provides the opportunity to estimate the systemic and pulmonary transit time dispersion <jats:italic>in\u00a0vivo<\/jats:italic>. The latter is determined by the flow heterogeneity in the microcirculatory network. Using this approach, we have analysed indocyanine green (<jats:styled-content style=\"fixed-case\">ICG<\/jats:styled-content>) disposition data obtained in four subjects by frequent early arterial blood sampling before and after beta\u2010adrenergic blockade by propranolol. Propranolol decreased cardiac output from 9\u00b73\u00a0\u00b1\u00a02\u00b78\u00a0l\u00a0min<jats:sup>\u22121<\/jats:sup> to 3\u00b75\u00a0\u00b1\u00a00\u00b747\u00a0l\u00a0min<jats:sup>\u22121<\/jats:sup> (<jats:italic>P<\/jats:italic>&lt;0\u00b705). This reduction was accompanied by a 4\u00b75\u00a0\u00b1\u00a00\u00b76\u2010fold and 2\u00b71\u00a0\u00b1\u00a00\u00b73\u2010fold increase (<jats:italic>P<\/jats:italic>&lt;0\u00b7001) in the relative dispersion (dimensionless variance) of blood transit times through the systemic and pulmonary circulation, respectively.<\/jats:p>","DOI":"10.1111\/cpf.12295","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T02:17:37Z","timestamp":1440469057000},"page":"270-275","source":"Crossref","is-referenced-by-count":0,"title":["Beta blockade increases pulmonary and systemic transit time heterogeneity: evaluation based on indocyanine green kinetics in healthy volunteers"],"prefix":"10.1111","volume":"37","author":[{"given":"Michael","family":"Weiss","sequence":"first","affiliation":[{"name":"Department of Pharmacology Martin Luther University Halle\u2010Wittenberg Halle Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom C.","family":"Krejcie","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and the Mary Beth Donnelley Clinical Pharmacology Core Facility Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Avram","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and the Mary Beth Donnelley Clinical Pharmacology Core Facility Feinberg School of Medicine Northwestern University Chicago IL 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