{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:08:12Z","timestamp":1787656092261,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The existing screening modalities for pulmonary embolism (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>), such as D\u2010dimer and clinical prediction rules, have low positive predictive values. With its capability to indicate pulmonary vascular abnormalities, the ratio of the transfer factor of the lungs for nitric oxide and the transfer factor of the lungs for carbon monoxide (<jats:italic>T<\/jats:italic><jats:sub>L,NO<\/jats:sub>\/<jats:italic>T<\/jats:italic><jats:sub>L,CO<\/jats:sub>) might be an additional discriminating parameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Carbon monoxide\/Nitric oxide diffusion measurements were performed on unselected patients seen on the emergency department for which due to suspected <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> a computed tomography pulmonary angiogram (<jats:styled-content style=\"fixed-case\">CTPA<\/jats:styled-content>) was ordered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 28 patients were included, <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> was found in 12 on <jats:styled-content style=\"fixed-case\">CTPA<\/jats:styled-content>. Median <jats:italic>T<\/jats:italic><jats:sub>L,NO<\/jats:sub>\/<jats:italic>T<\/jats:italic><jats:sub>L,CO<\/jats:sub> ratio was 4\u00b709 (interquartile range (IQR) 3\u00b783\u20134\u00b740) in the no <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group versus 4\u00b700 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 3\u00b778\u20134\u00b732) in the <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7959). Median alveolar volume was 77\u00b71% of predicted in the no <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group versus 71\u00b70% of predicted in the <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7353). Median <jats:italic>T<\/jats:italic><jats:sub>L,CO<\/jats:sub> was 75\u00b78% of predicted in the no <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group versus 68\u00b78% of predicted in the <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7120). Median <jats:italic>T<\/jats:italic><jats:sub>L,NO<\/jats:sub> was 69\u00b73% of predicted in the no <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group versus 60\u00b75% of predicted in the <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7078).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presented data indicate that the <jats:italic>T<\/jats:italic><jats:sub>L,NO<\/jats:sub>\/<jats:italic>T<\/jats:italic><jats:sub>L,CO<\/jats:sub> ratio cannot be used to exclude <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12317","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T05:01:03Z","timestamp":1447822863000},"page":"400-404","source":"Crossref","is-referenced-by-count":2,"title":["The <i>T<\/i><sub>L,NO<\/sub>\/<i>T<\/i><sub>L,CO<\/sub> ratio cannot be used to exclude pulmonary embolism"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7519-0206","authenticated-orcid":false,"given":"Timon M.","family":"Fabius","sequence":"first","affiliation":[{"name":"Department of Pulmonology Medisch Spectrum Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel M.","family":"Eijsvogel","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Medisch Spectrum Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"van der Lee","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Spaarne Hospital Hoofddorp The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein","family":"Brusse\u2010Keizer","sequence":"additional","affiliation":[{"name":"Medical School Twente Medisch Spectrum Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans H.","family":"de Jongh","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Medisch Spectrum Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.133405"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(87)80036-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.2.559"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00082112"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.08.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00180414"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034905"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.10.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2010.01000.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1957.11.2.290"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-8-200404200-00005"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052367"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00245.2009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.2.378"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.12.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.06.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613830"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(89)80130-1"}],"container-title":["Clinical 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