{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:41:49Z","timestamp":1781732509147,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:00:00Z","timestamp":1452729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In patients with fluid retention, the plasma clearance of<jats:sup>51<\/jats:sup>Cr\u2010<jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content>(Cl<jats:sub>exp<\/jats:sub>obtained by multiexponential fit) may overestimate the glomerular filtration rate (<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>). The present study was undertaken to compare a gamma\u2010variate plasma clearance (Cl<jats:sub>gv)<\/jats:sub>with the urinary plasma clearance of<jats:sup>51<\/jats:sup>Cr\u2010<jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content>(Cl<jats:sub>u<\/jats:sub>) in patients with cirrhosis with and without fluid retention. A total of 81 patients with cirrhosis (22 without fluid retention, 59 with ascites) received a quantitative intravenous injection of<jats:sup>51<\/jats:sup>Cr\u2010<jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content>followed by plasma and quantitative urinary samples for 5\u00a0h. Cl<jats:sub>gv<\/jats:sub>was determined from the injected dose relative to the plasma concentration\u2010time area, obtained by a gamma\u2010variate iterative fit. Cl<jats:sub>exp<\/jats:sub>and Cl<jats:sub>u<\/jats:sub>were determined by standard technique. In patients without fluid retention, Cl<jats:sub>gv<\/jats:sub>, Cl<jats:sub>exp<\/jats:sub>and Cl<jats:sub>u<\/jats:sub>were closely similar. The difference between Cl<jats:sub>gv<\/jats:sub>and Cl<jats:sub>u<\/jats:sub>(Cl<jats:sub>gv<\/jats:sub>\u2013 Cl<jats:sub>u<\/jats:sub>\u00a0=\u00a0\u0394Cl) was mean \u22120\u00b76\u00a0ml\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a01\u00b773\u00a0m<jats:sup>\u22122<\/jats:sup>. In patients with ascites, \u0394Cl was significantly higher (11\u00b78\u00a0ml\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a01\u00b773\u00a0m<jats:sup>\u22122<\/jats:sup>,<jats:italic>P<\/jats:italic>&lt;0\u00b70001), but this value was lower than Cl<jats:sub>exp<\/jats:sub>\u2013 Cl<jats:sub>u<\/jats:sub>(17\u00b75\u00a0mL\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a01\u00b773\u00a0m<jats:sup>\u22122<\/jats:sup>,<jats:italic>P<\/jats:italic>&lt;0\u00b701). \u0394Cl increased with lower values of<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>(<jats:italic>P<\/jats:italic>&lt;0\u00b7001). In conclusion, in patients with fluid retention and ascites Cl<jats:sub>gv<\/jats:sub>and Cl<jats:sub>exp<\/jats:sub>overestimates<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>substantially, but the overestimation is smaller with Cl<jats:sub>gv<\/jats:sub>. Although Cl<jats:sub>u<\/jats:sub>may underestimate<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>slightly, patients with ascites should collect urine quantitatively to obtain a reliable measurement of<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cpf.12336","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T11:23:26Z","timestamp":1452857006000},"page":"588-595","source":"Crossref","is-referenced-by-count":3,"title":["Gamma\u2010variate plasma clearance versus urinary plasma clearance of<sup>51<\/sup>Cr\u2010<scp>EDTA<\/scp>in patients with cirrhosis with and without fluid retention"],"prefix":"10.1111","volume":"37","author":[{"given":"Stefan","family":"Fuglsang","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, 239 Center for Functional and Diagnostic Imaging and Research Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik L.","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, 239 Center for Functional and Diagnostic Imaging and Research Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne B.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, 239 Center for Functional and Diagnostic Imaging and Research Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Gastro Unit Medical Division, 439 Hvidovre Hospital and Medical and Health Faculty University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens H.","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, 239 Center for Functional and Diagnostic Imaging and Research Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,14]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1","volume-title":"Ascites and Renal Dysfunction in Liver Disease","author":"Arroyo V","year":"1999"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.03.026"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209084290"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1985.tb00742.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365517609055255"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365516909081695"},{"key":"e_1_2_5_8_1","first-page":"1","volume-title":"The Kidney in Liver Disease","author":"Epstein M","year":"1996"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27829"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01736989"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-866-9_12"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12149"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1981.tb00881.x"},{"key":"e_1_2_5_15_1","first-page":"1","volume-title":"Ascites. Morgan & Claypool Life Sciences","author":"Henriksen JH","year":"2013"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)00009-X"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365518009095579"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00201.2004"},{"key":"e_1_2_5_19_1","first-page":"1","volume-title":"Basal Indikatorkinetics","author":"Henriksen JH","year":"2011"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2014.980313"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510802566882"},{"key":"e_1_2_5_22_1","first-page":"1725","article-title":"Bidirectional peritoneal transport of albumin in continous ambulatory peritoneal dialysis","volume":"10","author":"Joffe P","year":"1995","journal-title":"Kid Dial Transplant"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00175-1"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21901"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02319.x"},{"key":"e_1_2_5_26_1","first-page":"1","volume-title":"Tracer Kinetic Methods in Medical Physiology","author":"Lassen NA","year":"1979"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-1007-y"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.113.121004"},{"issue":"442","key":"e_1_2_5_29_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.0954-6820.1965.tb02318.x","article-title":"Determination of clearance and distribution volume with the single injection technique. In Denneberg T. Clinical studies on kidney function with radioactive sodium diatrizoate (Hypaque)","volume":"179","author":"Nosslin B","year":"1965","journal-title":"Acta Med Scand"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.26754"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-003-1341-8"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3283457466"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0660613"},{"key":"e_1_2_5_34_1","first-page":"114","volume-title":"Radionuclides in Nephrology","author":"Rehling M","year":"1999"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.14.6.502"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000255"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-010-9167-z"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1887-9"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.10.3.393"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcpf.12336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcpf.12336","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.12336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T20:35:01Z","timestamp":1718310901000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpf.12336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,14]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/cpf.12336"],"URL":"https:\/\/doi.org\/10.1111\/cpf.12336","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"value":"1475-0961","type":"print"},{"value":"1475-097X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,14]]}}}