{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T07:11:52Z","timestamp":1696057912858},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Myocardial perfusion imaging (<jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content>) holds an important place as non\u2010invasive risk assessment in patients with intermediate risk of coronary heart disease (<jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>). However, as much as 60\u201370% of <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> scans are normal. This study evaluates the role of coronary artery calcium scoring (<jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content> score) and <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010pro<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> as potential gatekeepers for <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content>. Patients with intermediate risk of <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> referred for standard <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> were included. <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content> score and <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010pro<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> were both assessed at the day of the stress study. Sensitivity, specificity and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> for prediction of abnormal <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> scans were calculated for <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> NT<\/jats:styled-content>\u2010pro<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> and the combination hereof. A total of 190 patients were included (mean age 61\u00a0\u00b1\u00a012\u00a0years, 55% female) of whom 24% had known <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>. In all 30% of the scans were abnormal. <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content> score achieved the highest <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> regardless of whether patients with known <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> were included or not [<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> 0\u00b775 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (0\u00b766\u20130\u00b784) and <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> 0\u00b779 (0\u00b768\u20130\u00b791)]. As a singular variable, <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content> score was the most potent predictor with a sensitivity of 85%, specificity of 39% and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> 88%. The combination of <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content> score&lt;10 and <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010pro<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>&gt;26 reached a sensitivity of 98% and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> 94%, where 8% of scans tentatively could be avoided. In patients referred for <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> with intermediate risk for <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>, a combination of <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content> score and <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010pro<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> could be used to identify a group of patients where <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> could be averted with a high degree of diagnostic safety.<\/jats:p>","DOI":"10.1111\/cpf.12363","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T03:06:42Z","timestamp":1458702402000},"page":"710-716","source":"Crossref","is-referenced-by-count":1,"title":["Coronary artery calcium score and N\u2010terminal pro\u2010B\u2010type natriuretic peptide as potential gatekeepers for myocardial perfusion imaging"],"prefix":"10.1111","volume":"37","author":[{"given":"Christian","family":"Haarmark","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology &amp; Nuclear Medicine Herlev and Gentofte Hospital University Hospital of Copenhagen Herlev Denmark"},{"name":"Department of Clinical Physiology &amp; Nuclear Medicine Bispebjerg Hospital University Hospital of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim Francis","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET Rigshospitalet University Hospital of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology &amp; Nuclear Medicine Herlev and Gentofte Hospital University Hospital of Copenhagen Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zerahn","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology &amp; Nuclear Medicine Herlev and Gentofte Hospital University Hospital of Copenhagen Herlev 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