{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:42:46Z","timestamp":1778931766615,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000145","name":"Alberta Innovates - Health Solutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Blood oxygen level\u2010dependent (<jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content>) functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>) studies of patients with cerebrovascular disease have largely ignored the confounds associated with abnormal cerebral blood flow, vascular reactivity and neurovascular coupling. We studied <jats:styled-content style=\"fixed-case\">BOLD fMRI<\/jats:styled-content> activation and cerebrovascular reactivity in moyamoya disease. To characterize the impact of remote vascular demands on <jats:styled-content style=\"fixed-case\">BOLD fMRI<\/jats:styled-content> measurements, we varied the vascular territories engaged by manipulating the experimental task performed by the participants. Vascular territories affected by disease were identified using <jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content> cerebrovascular reactivity. Preliminary evidence from two patients pre\u2010 and postrevascularization surgery and four controls indicates that neurovascular coupling in affected brain regions can be modulated by the task\u2010related vascular demands in unaffected regions. In one patient studied, we observed that brain regions with improved cerebrovascular reactivity after surgery demonstrated normalized neurovascular coupling, that is the degree to which neurovascular coupling was modulated by task\u2010related vascular demands was decreased. We propose that variations in task\u2010dependent neurovascular coupling in patients with moyamoya disease are likely related to vascular steal. While preliminary, our findings are a proof of concept of the limitations of <jats:styled-content style=\"fixed-case\">BOLD fMRI<\/jats:styled-content> in cerebrovascular disease and suggest a role for assessment of cerebrovascular reactivity to improve interpretation of task\u2010related <jats:styled-content style=\"fixed-case\">BOLD fMRI<\/jats:styled-content> activation.<\/jats:p>","DOI":"10.1111\/cpf.12387","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T09:22:42Z","timestamp":1472548962000},"page":"87-92","source":"Crossref","is-referenced-by-count":18,"title":["Impact of abnormal cerebrovascular reactivity on <scp>BOLD fMRI<\/scp>: a preliminary investigation of moyamoya disease"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-8605","authenticated-orcid":false,"given":"Erin L.","family":"Mazerolle","sequence":"first","affiliation":[{"name":"Department of Radiology Hotchkiss Brain Institute University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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