{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:40:27Z","timestamp":1789749627242,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T00:00:00Z","timestamp":1481068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Pulmonary hypertension (<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>) patients have high mortality due to right ventricular failure. Predictors of poor prognostic outcome are increased right atrial volume (<jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content>) and elevated mean right atrial pressure (<jats:styled-content style=\"fixed-case\">mRAP<\/jats:styled-content>). Our aim was to determine whether <jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content> measured with 2D echocardiography (2<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>) and 3D echocardiography (3<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>) can detect elevated <jats:styled-content style=\"fixed-case\">mRAP<\/jats:styled-content> in patients evaluated for PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 85 patients prospectively evaluated for <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>, 44 patients (63\u00a0\u00b1\u00a015\u00a0years, 57% female) had 2<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>, 3<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content> and right heart catheterization within 48\u00a0h and were in sinus rhythm. Maximum (<jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content><jats:sub>max<\/jats:sub>) and minimum (<jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content><jats:sub>min<\/jats:sub>) volumes were measured with 3<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>. 2D maximum <jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> area, inferior vena cava diameter and collapsibility were measured. Invasive <jats:styled-content style=\"fixed-case\">mRAP<\/jats:styled-content>\u00a0&gt;\u00a08\u00a0mmHg was predefined as elevated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content><jats:sub>max<\/jats:sub> and <jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content><jats:sub>min<\/jats:sub> correlated with <jats:styled-content style=\"fixed-case\">mRAP<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b740 and <jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b735, <jats:italic>P<\/jats:italic>&lt;0\u00b705, for both), and so did 2<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content> maximum <jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b742, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005) and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> area (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b740, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008). Area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) from receiver\u2010operating characteristics curves was for 3<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content> 0\u00b777 for <jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content><jats:sub>max<\/jats:sub>, 0\u00b774 for <jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content><jats:sub>min<\/jats:sub>, from 2<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>, 0\u00b776 for maximum <jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content> and 0\u00b775 for <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> area to discriminate elevated <jats:styled-content style=\"fixed-case\">mRAP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>&lt;0\u00b701 for all). <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> patients had larger 3D <jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content> compared with controls (<jats:italic>P<\/jats:italic>&lt;0\u00b701). <jats:styled-content style=\"fixed-case\">IVC<\/jats:styled-content> diameter correlated with <jats:styled-content style=\"fixed-case\">mRAP<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b741, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7007), but collapsibility did not (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7078). <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> was neither significant for <jats:styled-content style=\"fixed-case\">IVC<\/jats:styled-content> diameter nor for collapsibility for predicting <jats:styled-content style=\"fixed-case\">mRAP<\/jats:styled-content>&gt;8\u00a0mmHg. The optimal threshold was 57\u00a0ml\u00a0m<jats:sup>\u22122<\/jats:sup> for <jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content><jats:sub>max<\/jats:sub>, 31\u00a0ml\u00a0m<jats:sup>\u22122<\/jats:sup> for <jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content><jats:sub>min<\/jats:sub> and 36\u00a0ml\u00a0m<jats:sup>\u22122<\/jats:sup> for 2DE RAV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Enlarged <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> measures with 2<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content> and 3<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content> have better discriminatory ability compared with <jats:styled-content style=\"fixed-case\">IVC<\/jats:styled-content> measures, to detect elevated <jats:styled-content style=\"fixed-case\">mRAP<\/jats:styled-content> in patients evaluated for <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12398","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T12:23:28Z","timestamp":1481113408000},"page":"192-199","source":"Crossref","is-referenced-by-count":7,"title":["Discriminatory ability of right atrial volumes with two\u2010 and three\u2010dimensional echocardiography to detect elevated right atrial pressure in pulmonary hypertension"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2655-2423","authenticated-orcid":false,"given":"Ellen","family":"Ostenfeld","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Skane University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Werther\u2010Evaldsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Cardiology, Section\u00a0for Heart Failure and Valvular Disease Skane University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Engblom","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Skane University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Ingvarsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Cardiology, Section\u00a0for Heart Failure and Valvular Disease Skane University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Roijer","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Cardiology, Section\u00a0for Heart Failure and Valvular Disease Skane University Hospital Lund University Lund 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