{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:01:54Z","timestamp":1774929714733,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Heart rate recovery (HRR) is a strong mortality predictor. Exercise training (ET) and \u03b2\u2010blocker therapy have significant impact on the HRR of patients following myocardial infarction (MI). However, the combination of ET and \u03b2\u2010blocker therapy, as well as its effectiveness in patients with a more compromised HRR (\u226412\u00a0bpm), has been under\u2010studied. Male patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a064) post\u2010MI were divided: Training\u00a0+\u00a0\u03b2\u2010blocker (<jats:italic>n<\/jats:italic>\u00a0=\u00a019), Training (<jats:italic>n<\/jats:italic>\u00a0=\u00a015), \u03b2\u2010blocker (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) and Control (<jats:italic>n<\/jats:italic>\u00a0=\u00a019). Participants performed an ergometric test before and after 3\u00a0months of intervention. HRR was obtained during 5\u00a0min of recovery and corrected by the cardiac reserve (HRR<jats:sub>corrCR<\/jats:sub>). Compared to pre\u2010intervention, HRR<jats:sub>corrCR<\/jats:sub> was significantly increased during the 1st and 2nd minutes of recovery in the Training\u00a0+\u00a0\u03b2\u2010blocker group (70\u00b75% and 37\u00b75%, respectively; <jats:italic>P<\/jats:italic>&lt;0\u00b705). A significant improvement, lasting from the 1st to the 4th minute of recovery, was also observed in the Training group (47%, 50%, 25% and 8\u00b77%, respectively; <jats:italic>P<\/jats:italic>&lt;0\u00b705). In contrast, the \u03b2\u2010blocker group showed a reduction in HRR<jats:sub>corrCR<\/jats:sub> during the 2nd and 3rd minutes of recovery (\u221221\u00b72% and \u221216\u00b73%, respectively; <jats:italic>P<\/jats:italic>&lt;0\u00b705). In addition, interventions involving ET (Training\u00a0+\u00a0\u03b2b, Training) were significantly more effective in patients with a pre\u2010intervention HRR\u00a0\u2264\u00a012\u00a0bpm than for patients with HRR\u00a0&gt;\u00a012\u00a0bpm. Combination of \u03b2\u2010blocker therapy with ET does not compromise the effect of training and instead promotes HRR and aerobic capacity improvement. In addition, this combination is particularly beneficial for individuals presenting with a more compromised HRR. However, chronic administration of \u03b2\u2010blocker therapy alone did not promote improvement in HRR or aerobic capacity.<\/jats:p>","DOI":"10.1111\/cpf.12420","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T10:32:51Z","timestamp":1491993171000},"page":"351-359","source":"Crossref","is-referenced-by-count":18,"title":["Heart rate recovery improvement in patients following acute myocardial infarction: exercise training, \u03b2\u2010blocker therapy or both"],"prefix":"10.1111","volume":"38","author":[{"given":"Wladimir M.","family":"Medeiros","sequence":"first","affiliation":[{"name":"Laboratory of Exercise Physiology and Cardiac Rehabilitation (GERFE) Department of Medicine and Physiotherapy Santo Amaro University (UNISA) S\u00e3o Paulo Brazil"},{"name":"Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE) Respiratory Division Department of Medicine Federal University of S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"},{"name":"Department of Rehabilitation and Functional Capacity School of Physiotherapy Ibirapuera University (UNIB) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio A.","family":"de Luca","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Physiology and Cardiac Rehabilitation (GERFE) Department of Medicine and Physiotherapy Santo Amaro University (UNISA) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alcides R.","family":"de Figueredo J\u00fanior","sequence":"additional","affiliation":[{"name":"Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE) Respiratory Division Department of Medicine Federal University of S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe A. 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