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Twelve trained men performed exercise in three conditions: normoxia (fraction of inspired oxygen [<jats:styled-content style=\"fixed-case\">F<jats:sub>I<\/jats:sub>O<\/jats:styled-content><jats:sub>2<\/jats:sub>]\u00a0=\u00a021%), moderate\u2010level hypoxia (<jats:styled-content style=\"fixed-case\">F<jats:sub>I<\/jats:sub>O<\/jats:styled-content><jats:sub>2<\/jats:sub>\u00a0=\u00a016%) and high\u2010level hypoxia (<jats:styled-content style=\"fixed-case\">F<jats:sub>I<\/jats:sub>O<\/jats:styled-content><jats:sub>2<\/jats:sub>\u00a0=\u00a013%). Exercise comprised high\u2010load squats and deadlifts (5\u00a0\u00d7\u00a05 using 80% of 1\u2010repetition maximum with 180\u2010s rest). Muscle oxygenation and activation were monitored during exercise. Metabolic stress was estimated via capillary blood sampling. Perceived fatigue and soreness were also quantified following exercise. While the hypoxic conditions appeared to affect muscle oxygenation, significant differences between conditions were only noted for maximal deoxyhaemoglobin in the deadlift (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7009). Blood lactate concentration increased from 1\u00b71 to 1\u00b72\u00a0mmol\u00a0l<jats:sup>\u22121<\/jats:sup> at baseline to 9\u00b75\u20139\u00b78\u00a0mmol\u00a0l<jats:sup>\u22121<\/jats:sup> after squats and 10\u00b74\u201310\u00b75\u00a0mmol\u00a0l<jats:sup>\u22121<\/jats:sup> after deadlifts (<jats:italic>P<\/jats:italic>\u22640\u00b7001), although there were no between\u2010condition differences. Perceived fatigue and muscle soreness were significantly elevated immediately and at 24\u00a0h following exercise, respectively, by similar magnitudes in all conditions (<jats:italic>P<\/jats:italic>\u22640\u00b7001). Muscle activation did not differ between conditions. While metabolic stress is thought to moderate muscle activation and subsequent muscular development during hypoxic resistance training, it is not augmented during traditional high\u2010load exercise. This may be explained by the low number of repetitions performed and the long interset rest periods employed during this training. These findings suggest that high\u2010load resistance training might not benefit from additional hypoxia as has been shown for low\u2010 and moderate\u2010load training.<\/jats:p>","DOI":"10.1111\/cpf.12451","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T10:06:48Z","timestamp":1501236408000},"page":"595-602","source":"Crossref","is-referenced-by-count":11,"title":["Acute physiological and perceptual responses to high\u2010load resistance exercise in hypoxia"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2484-4019","authenticated-orcid":false,"given":"Brendan R.","family":"Scott","sequence":"first","affiliation":[{"name":"School of Psychology and Exercise Science Murdoch University Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie M.","family":"Slattery","sequence":"additional","affiliation":[{"name":"New South Wales Institute of Sport Sydney Olympic Park NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean V.","family":"Sculley","sequence":"additional","affiliation":[{"name":"Biomedical Sciences and Pharmacy Faculty of Health and Medicine University of Newcastle Ourimbah NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Applied Sports Science and Exercise Testing Laboratory Faculty of Science and Information Technology University of Newcastle Ourimbah NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah J.","family":"Peiffer","sequence":"additional","affiliation":[{"name":"School of Psychology and Exercise Science Murdoch University Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben J.","family":"Dascombe","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Nutrition and Sport La Trobe University Bundoora VIC 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