{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:01:56Z","timestamp":1790517716590,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005646","name":"Actelion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Right ventricular (RV<\/jats:styled-content>) dysfunction may be caused by either pressure or volume overload. RV<\/jats:styled-content> function is conventionally assessed with echocardiography using tricuspid annular plane systolic excursion (TAPSE<\/jats:styled-content>), RV<\/jats:styled-content> fractional area change (RVFAC<\/jats:styled-content>), tricuspid lateral annular systolic velocity (S\u2032) and RV<\/jats:styled-content> index of myocardial performance (RIMP<\/jats:styled-content>). The purpose of this study was to evaluate whether RV<\/jats:styled-content> global longitudinal strain (RVGLS<\/jats:styled-content>) and RV<\/jats:styled-content>\u2010free wall strain (RV<\/jats:styled-content>\u2010free) could add additional information to differentiate these two causes of RV<\/jats:styled-content> overload.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>The study enrolled 89 patients with an echocardiographic trans\u2010tricuspid gradient >30\u00a0mmHg. Forty\u2010five patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (pressure overload) were compared with 44 patients with an atrial septum defect (volume overload). RV<\/jats:styled-content> size was larger in the volume group (P<\/jats:italic><0\u00b705). TAPSE<\/jats:styled-content> and S\u2032 were lower in the pressure group (P<\/jats:italic><0\u00b705, P<\/jats:italic><0\u00b701). RVFAC<\/jats:styled-content> was lower in the pressure group (P<\/jats:italic><0\u00b7001) as well as RVGLS<\/jats:styled-content> (\u221212\u00b71\u00a0\u00b1\u00a03\u00b73% versus \u221220\u00b72\u00a0\u00b1\u00a03\u00b74%, P<\/jats:italic><0\u00b7001) and RV<\/jats:styled-content>\u2010free (\u221212\u00b79\u00a0\u00b1\u00a03\u00b73% versus \u221219\u00b74\u00a0\u00b1\u00a03\u00b74%, P<\/jats:italic><0\u00b7001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In this study, RVGLS<\/jats:styled-content> and RV<\/jats:styled-content>\u2010free could more accurately discriminate RV<\/jats:styled-content> pressure from volume overload than conventional measures. The reason could be that TAPSE<\/jats:styled-content> and S\u2032 are unable to differentiate active deformation from passive entrainment caused by the left ventricle. The pressure group had evidence of marked RV<\/jats:styled-content> hypertrophy despite standard functional parameters (TAPSE<\/jats:styled-content> and S) within normal range. This would enhance the value of strain to more sensitively detect abnormal function. A cut\u2010off value of below \u221216% for RVGLS<\/jats:styled-content> and RV<\/jats:styled-content>\u2010free predicts RV<\/jats:styled-content> pressure overload with high accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12477","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T02:18:44Z","timestamp":1509070724000},"page":"763-771","source":"Crossref","is-referenced-by-count":21,"title":["Right ventricular speckle tracking assessment for differentiation of pressure\u2010 versus volume\u2010overloaded right ventricle"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9509-7199","authenticated-orcid":false,"given":"Anna","family":"Werther Evaldsson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund, Cardiology Lund University Lund Sweden"},{"name":"The Section\u00a0for Heart Failure and Valvular Disease VO Heart and Lung medicine Skane University Hospital Lund 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