{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:29:49Z","timestamp":1770985789329,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007308","name":"Sveriges L\u00e4karf\u00f6rbund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007308","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Regional ventricular pumping mechanisms in patients with volume\u2010loaded right ventricles (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) are altered, but the cause is unknown. The aim was to determine whether these changes in ventricular pumping mechanisms are influenced by the <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> dilatation itself or the aetiology behind it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen patients with atrial septal defects (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) and 10 healthy controls underwent cardiovascular magnetic resonance (<jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content>) at rest and during dobutamine\/atropine stress. Sixteen patients underwent transcutaneous <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> closure. Follow\u2010up <jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content> at rest was performed the following day. Thirty patients with <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> overload due to pulmonary regurgitation (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) underwent <jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content> at rest. Cine images were used to measure left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> volumes as well as septal, longitudinal and lateral contributions to <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> stroke volume (<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At rest, septal contribution to <jats:styled-content style=\"fixed-case\">LVSV<\/jats:styled-content> was lower in <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients than controls (\u22121% versus 7%, <jats:italic>P<\/jats:italic>&lt;0\u00b705), but there was no difference in longitudinal or lateral contribution to <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>. Patients with <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> had lower longitudinal contribution to <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> with increased lateral and septal contribution. During dobutamine stress, longitudinal contribution to <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RVSV<\/jats:styled-content> decreased and lateral contribution increased for <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients and controls. The day after <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> closure, septal contribution to <jats:styled-content style=\"fixed-case\">LVSV<\/jats:styled-content> was 6%, longitudinal contribution had increased for <jats:styled-content style=\"fixed-case\">RVSV<\/jats:styled-content> (<jats:italic>P<\/jats:italic>&lt;0\u00b705) and decreased for <jats:styled-content style=\"fixed-case\">LVSV<\/jats:styled-content> (<jats:italic>P<\/jats:italic>&lt;0\u00b701).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pumping mechanisms in patients with <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> volume overload depend on the aetiology for the <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> dilation and not the size of the <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12491","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T10:12:44Z","timestamp":1513159964000},"page":"830-839","source":"Crossref","is-referenced-by-count":9,"title":["Alterations in ventricular pumping in patients with atrial septal defect at rest, during dobutamine stress and after defect closure"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0544-2153","authenticated-orcid":false,"given":"Sigurdur S.","family":"Stephensen","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Clinical Physiology Lund University Lund Sweden"},{"name":"Department of Pediatric Cardiology Lund University Hospital Lund University Lund 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