{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:24:45Z","timestamp":1790623485246,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study compared the effects of low and high weekly exercise frequencies on microvascular endothelium function and oxidative stress among patients with coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010four male patients completed a 6\u2010month cardiac rehabilitation programme, from which 23 performed exercise with a high frequency (HF) and 11 with a low frequency (LF). Systemic microvascular blood flow, maximal aerobic capacity, blood lipids, oxidative stress and anthropometric data were assessed prior to and after the cardiac rehabilitation programme. Microvascular blood flow was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresis of acetylcholine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Maximal aerobic capacity, biochemical analysis and anthropometric data were similar between groups prior to and after the cardiac rehabilitation programme (\n                      <jats:italic>P<\/jats:italic>\n                      &gt;0\u00b705). However, after 6\u00a0months of cardiac rehabilitation performed with HF, there was an increase in the peak response to acetylcholine compared with LF (83\u00b75\u00a0\u00b1\u00a058\u00b75 versus 21\u00b78\u00a0\u00b1\u00a022\u00b74%;\n                      <jats:italic>P&lt;<\/jats:italic>\n                      0\u00b705). Changes in lipid peroxidation (HF: \u22125\u00b75\u00a0\u00b1\u00a09\u00b74 versus LF: 2\u00b72\u00a0\u00b1\u00a012\u00b70\u00a0pmol MDA\u00a0mg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00\u00b719), catalase activity (HF: 0\u00b707\u00a0\u00b1\u00a00\u00b717 versus LF: 0\u00b704\u00a0\u00b1\u00a00\u00b708 U\u00a0mg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00\u00b774) and nitric oxide levels (HF: 1\u00b78\u00a0\u00b1\u00a015\u00b73 versus LF: \u22123\u00b72\u00a0\u00b1\u00a012\u00b73\u00a0\u03bcM;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00\u00b736) were similar between groups after cardiac rehabilitation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Six months of aerobic exercise training performed with high frequency is preferable to low frequency aiming endothelium microvascular function increases in patients with coronary artery disease. The mechanisms involved in this response are unclear and warrant additional research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cpf.12492","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T02:52:42Z","timestamp":1514343162000},"page":"840-846","source":"Crossref","is-referenced-by-count":18,"title":["The impact of exercise frequency upon microvascular endothelium function and oxidative stress among patients with coronary artery disease"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3581-7251","authenticated-orcid":false,"given":"Juliana P.","family":"Borges","sequence":"first","affiliation":[{"name":"Laboratory of Physical Activity and Health Promotion State University of Rio de Janeiro Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro R.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ministry of Health Rio de Janeiro"},{"name":"Laboratory of Cardiovascular Investigation Oswaldo Cruz Institute Oswaldo Cruz Foundation Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella O.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Activity and Health Promotion State University of Rio de Janeiro Rio de Janeiro"},{"name":"National Institute of Cardiology Ministry of Health Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J. 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