{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T19:14:06Z","timestamp":1770146046087,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>) affects about 25% of the population worldwide. <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> may be viewed as the hepatological manifestation of metabolic syndrome. Patients with metabolic syndrome due to diabetes or obesity have an increased risk of cardiovascular disease. This narrative review describes cardiometabolic effects of antidiabetic drugs in <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic search in PubMed and manually scanned bibliographies in trial databases and reference lists in relevant articles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Heart disease is the leading cause of death in <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>. Conversely, <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> is an independent cardiovascular risk factor in patients suffering from metabolic syndrome. <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> is associated with markers of atherosclerosis, and patients have increased risk of ischaemic heart disease. Additionally, patients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> have increased risk of cardiac dysfunction and heart failure. There are no randomized controlled trials showing clear effects of medical treatment on clinical outcomes in patients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>. However, based on evidence from small trials and extrapolation from trials evaluating patients with type 2 diabetes, some antidiabetic drugs may be beneficial on cardiovascular function in patients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At present, there is promising evidence of a potential effect of antidiabetic drugs for patients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>. Future studies should address the treatment of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> and the liver\u2010related consequences but also aim at improving the cardiometabolic outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12526","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T09:26:29Z","timestamp":1527585989000},"page":"122-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiometabolic effects of antidiabetic drugs in non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9381-4852","authenticated-orcid":false,"given":"Iben","family":"Rix","sequence":"first","affiliation":[{"name":"Gastrounit Medical Division Hvidovre Hospital University of Copenhagen Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Steen 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