{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:44:35Z","timestamp":1758278675214,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T00:00:00Z","timestamp":1538265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","award":["11\u201010\u2010R87\u2010B\u2010A3628\u201022678"],"award-info":[{"award-number":["11\u201010\u2010R87\u2010B\u2010A3628\u201022678"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007460","name":"Arvid Nilssons Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009459","name":"Hvidovre Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Combined coronary CT angiography and CT perfusion (CTP) is a novel, non\u2010invasive, \u2018one\u2010stop\u2019 diagnostic tool to rule out ischaemia in patients suspected for coronary artery disease (CAD). However, the normal myocardial perfusion pattern by static CTP in humans is poorly described. We aimed to investigate global and regional myocardial perfusion during rest and adenosine\u2010induced hyperaemia in asymptomatic women without history of coronary heart disease (CHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a 320\u2010row CT scanner with a static protocol, semi\u2010quantitative assessment of rest and stress CTP was performed in 34 asymptomatic middle\u2010aged women without obstructive CAD (&lt;50% stenosis) or history of CHD, and with normal exercise stress test and left ventricular (LV) function. Using a 16\u2010segment model, we assessed global and regional values of LV myocardial perfusion reserve (MPR) and transmural perfusion ratio (TPR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean\u00b1SD age was 56\u00a0\u00b1\u00a013\u00a0years. Resting and hyperaemic myocardial perfusion was heterogeneously distributed throughout the LV myocardium. During hyperaemia, global MPR increased by median (IQR) 158% (144\u2013176) with the highest increase in the right coronary artery territory (171%; <jats:italic>P<\/jats:italic>&lt;0.02). Rest and stress segmental TPR values ranged between 0.93\u20101.26 and 0.99\u20101.13, respectively, with the lowest values detected in the inferoseptal segments. No differences in perfusion parameters were found between participants with normal epicardial arteries and participants with non\u2010significant epicardial atheromatosis (all <jats:italic>P<\/jats:italic>&gt;0.05). Global perfusion parameters were not associated with age or menopausal status (all <jats:italic>P<\/jats:italic>&gt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This descriptive study presents data on global and regional myocardial perfusion in a cohort of healthy middle\u2010aged women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12542","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T01:40:07Z","timestamp":1538358007000},"page":"65-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-4848","authenticated-orcid":false,"given":"Daria Frestad","family":"Bechsgaard","sequence":"first","affiliation":[{"name":"Department of Cardiology Hvidovre University 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