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No specific recommendation is available on how exercise training should be conducted and evaluated after aortic valve replacement (<jats:styled-content style=\"fixed-case\">AVR<\/jats:styled-content>). This study aimed to examine the effect of aerobic exercise training on exercise capacity following <jats:styled-content style=\"fixed-case\">AVR<\/jats:styled-content>. In addition to our primary outcome variable, peak oxygen uptake (peak<jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub>), the effect on submaximal cardiopulmonary variables including oxygen uptake kinetics (tau), oxygen uptake efficiency slope (<jats:styled-content style=\"fixed-case\">OUES<\/jats:styled-content>) and ventilatory efficiency (<jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">VCO<\/jats:styled-content><jats:sub>2<\/jats:sub> slope) was evaluated. Following <jats:styled-content style=\"fixed-case\">AVR<\/jats:styled-content> due to <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>, 12 patients were randomized to either a group receiving 12\u00a0weeks of supervised aerobic exercise training (<jats:styled-content style=\"fixed-case\">EX<\/jats:styled-content>) or a control group (<jats:styled-content style=\"fixed-case\">CON<\/jats:styled-content>). Exercise capacity was assessed by a maximal cardiopulmonary exercise test (<jats:styled-content style=\"fixed-case\">CPET<\/jats:styled-content>). There was a significant increase in peak load (+28%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7031) and in peak<jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub> (+23%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7031) in <jats:styled-content style=\"fixed-case\">EX<\/jats:styled-content>, corresponding to an increase in achieved percentage of predicted peak<jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub> from 88 to 104% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7031). For submaximal variables, there were only non\u2010statistically significant trends in improvement between <jats:styled-content style=\"fixed-case\">CPET<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">EX<\/jats:styled-content>. In <jats:styled-content style=\"fixed-case\">CON<\/jats:styled-content>, there were no significant differences in any maximal or submaximal variable between <jats:styled-content style=\"fixed-case\">CPET<\/jats:styled-content>s. We conclude that 12\u00a0weeks of supervised aerobic exercise training induces significant adaptations in cardiopulmonary function following <jats:styled-content style=\"fixed-case\">AVR<\/jats:styled-content>, especially in regard to maximal variables including peak<jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub>. In addition, we provide novel data on the effect on several submaximal variables following exercise training in this group of patients.<\/jats:p>","DOI":"10.1111\/cpf.12545","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T04:20:19Z","timestamp":1539058819000},"page":"103-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cardiopulmonary exercise testing for evaluation of a randomized exercise training intervention following aortic valve replacement"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8732-239X","authenticated-orcid":false,"given":"Henric","family":"Nilsson","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Department of Medical and Health Sciences Link\u00f6ping University Link\u00f6ping 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