{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:33:43Z","timestamp":1777901623340,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011077","name":"Sk\u00e5nes universitetssjukhus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Summary<\/jats:title>Purpose<\/jats:title>Patients with pulmonary arterial hypertension (PAH<\/jats:styled-content>) due to systemic sclerosis (SS<\/jats:styled-content>c) have high mortality. Left ventricular (LV<\/jats:styled-content>) peak global longitudinal strain (GLS<\/jats:styled-content>) is decreased in SS<\/jats:styled-content>c. It is unknown whether low GLS<\/jats:styled-content> is due to SS<\/jats:styled-content>c or PAH<\/jats:styled-content>. Therefore, our primary aim was to evaluate both LV<\/jats:styled-content> and right ventricular free wall GLS<\/jats:styled-content> (RVFW GLS<\/jats:styled-content>) in SS<\/jats:styled-content>c, with and without PAH<\/jats:styled-content>, using cardiac magnetic resonance with feature tracking. Secondary aim was to relate GLS<\/jats:styled-content> to invasive mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty\u2010eight patients with SS<\/jats:styled-content>c, 19 patients with SS<\/jats:styled-content>c\u2010PAH<\/jats:styled-content> and 19 healthy controls for comparison, were included. Endocardial and epicardial borders were delineated in cine images (short\u2010axis stack and three long\u2010axis views) for volumetric and strain calculations.<\/jats:p><\/jats:sec>Results<\/jats:title>Systemic sclerosis\u2010PAH<\/jats:styled-content> had lower LV<\/jats:styled-content> and RVFW GLS<\/jats:styled-content> than SS<\/jats:styled-content>c (LV<\/jats:styled-content>: P<\/jats:italic>\u00a0=\u00a00\u00b701, RV<\/jats:styled-content>: P<\/jats:italic><0\u00b7001) and controls (LV<\/jats:styled-content>: P<\/jats:italic>\u00a0=\u00a00\u00b702; RV<\/jats:styled-content>: P<\/jats:italic><0\u00b7001), with no difference between SS<\/jats:styled-content>c and controls. LV<\/jats:styled-content> strain correlated with mPAP<\/jats:styled-content> (R<\/jats:italic>\u00a0=\u00a00\u00b742, P<\/jats:italic>\u00a0=\u00a00\u00b703) and PVR<\/jats:styled-content> (R<\/jats:italic>\u00a0=\u00a00\u00b752, P<\/jats:italic>\u00a0=\u00a00\u00b7006). RVFW GLS<\/jats:styled-content> correlated with mPAP<\/jats:styled-content> (R<\/jats:italic>\u00a0=\u00a00\u00b768, P<\/jats:italic><0\u00b7001) and PVR<\/jats:styled-content> (R<\/jats:italic>\u00a0=\u00a00\u00b759, P<\/jats:italic>\u00a0=\u00a00\u00b7001). ROC<\/jats:styled-content> curves for predicting PAH<\/jats:styled-content> had AUC<\/jats:styled-content> 0\u00b773 for LV<\/jats:styled-content> strain (P<\/jats:italic>\u00a0=\u00a00\u00b7003) and 0\u00b786 for RVFW GLS<\/jats:styled-content> (P<\/jats:italic><0\u00b7001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Lower GLS<\/jats:styled-content> is mainly determined by increased pulmonary pressure and not by SS<\/jats:styled-content>c per se<\/jats:italic>. Low LV<\/jats:styled-content> and RVFW GLS<\/jats:styled-content> are indicative of increased mPAP<\/jats:styled-content> and PVR<\/jats:styled-content>, which opens for improved non\u2010invasive methods to select patients eligible for right heart catheterization and to monitor the effects of PAH<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12561","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:45:06Z","timestamp":1546296306000},"page":"215-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Decreased biventricular longitudinal strain in patients with systemic sclerosis is mainly caused by pulmonary hypertension and not by systemic sclerosis per se<\/i>"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1925-5092","authenticated-orcid":false,"given":"Anthony","family":"Lindholm","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Hesselstrand","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Rheumatology Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"R\u00e5degran","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Cardiology Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"Arheden","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2655-2423","authenticated-orcid":false,"given":"Ellen","family":"Ostenfeld","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Sk\u00e5ne University Hospital Lund University Lund 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