{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:38:09Z","timestamp":1768275489263,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Ageing reduces cerebral blood flow (CBF), while mean arterial pressure (MAP) becomes elevated. According to \u2018the selfish brain\u2019 hypothesis of hypertension, a reduction in vertebral artery blood flow (VA) leads to increased sympathetic activity and thus increases MAP. In twenty\u2010two young (24\u00a0\u00b1\u00a03\u00a0years; mean\u00a0\u00b1\u00a0SD) and eleven elderly (70\u00a0\u00b1\u00a05\u00a0years) normotensive men, duplex ultrasound evaluated whether the age\u2010related reduction in CBF affects VA more than internal carotid artery (ICA) blood flow. Pulse\u2010contour analysis evaluated MAP while near\u2010infrared spectroscopy determined frontal lobe oxygenation and transcranial Doppler middle cerebral artery mean blood velocity (MCA V<jats:sub>mean<\/jats:sub>). During supine rest, MAP (90\u00a0\u00b1\u00a013 versus 78\u00a0\u00b1\u00a09\u00a0mmHg; <jats:italic>P<\/jats:italic>&lt;0\u00b7001) was elevated in the older subjects while their frontal lobe oxygenation (68\u00a0\u00b1\u00a07% versus 77\u00a0\u00b1\u00a07%; <jats:italic>P<\/jats:italic>&lt;0\u00b7001), MCA V<jats:sub>mean<\/jats:sub> (49\u00a0\u00b1\u00a09 versus 60\u00a0\u00b1\u00a012\u00a0cm s<jats:sup>\u22121<\/jats:sup>; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7016) and CBF (754\u00a0\u00b1\u00a0112 versus 900\u00a0\u00b1\u00a0144\u00a0ml\u00a0min<jats:sup>\u22121<\/jats:sup>; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7004) were low reflected in VA (138\u00a0\u00b1\u00a048 versus 219\u00a0\u00b1\u00a050\u00a0ml\u00a0min<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic>&lt;0\u00b7001) rather than in ICA flow (616\u00a0\u00b1\u00a096 versus 680\u00a0\u00b1\u00a0120\u00a0ml\u00a0min<jats:sup>\u22121<\/jats:sup>; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7099). In conclusion, blood supply to the brain and its oxygenation are affected by ageing and the age\u2010related decline in VA flow appears to be four times as large as that in ICA and could be important for the age\u2010related increase in MAP.<\/jats:p>","DOI":"10.1111\/cpf.12568","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T18:38:43Z","timestamp":1553193523000},"page":"255-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The age\u2010related reduction in cerebral blood flow affects vertebral artery more than internal carotid artery blood flow"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1233-0413","authenticated-orcid":false,"given":"Niels D.","family":"Olesen","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Biomedical Sciences 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