{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:28:26Z","timestamp":1792128506685,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006738","name":"Medicinska Fakulteten, Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2011\u20103916"],"award-info":[{"award-number":["2011\u20103916"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2011\u20104078"],"award-info":[{"award-number":["2011\u20104078"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2012\u20104944"],"award-info":[{"award-number":["2012\u20104944"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Blood flow measurements in the ascending aorta and pulmonary artery from phase\u2010contrast magnetic resonance images require accurate time\u2010resolved vessel segmentation over the cardiac cycle. Current semi\u2010automatic segmentation methods often involve time\u2010consuming manual correction, relying on user experience for accurate results. The purpose of this study was to develop a semi\u2010automatic vessel segmentation algorithm with shape constraints based on manual vessel delineations for robust segmentation of the ascending aorta and pulmonary artery, to evaluate the proposed method in healthy volunteers and patients with heart failure and congenital heart disease, to validate the method in a pulsatile flow phantom experiment, and to make the method freely available for research purposes. Algorithm shape constraints were extracted from manual reference delineations of the ascending aorta (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and pulmonary artery (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and were included in a semi\u2010automatic segmentation method only requiring manual delineation in one image. Bias and variability (bias\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) for flow volume of the proposed algorithm versus manual reference delineations were 0\u00b70\u00a0\u00b1\u00a01\u00b79\u00a0ml in the ascending aorta (<jats:italic>n<\/jats:italic>\u00a0=\u00a0151; seven healthy volunteers; 144 heart failure patients) and \u22121\u00b77\u00a0\u00b1\u00a02\u00b79\u00a0ml in the pulmonary artery (<jats:italic>n<\/jats:italic>\u00a0=\u00a040; 25 healthy volunteers; 15 patients with atrial septal defect). Interobserver bias and variability were lower (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008) for the proposed semi\u2010automatic method (\u22120\u00b71\u00a0\u00b1\u00a00\u00b79\u00a0ml) compared to manual reference delineations (1\u00b75\u00a0\u00b1\u00a05\u00b71\u00a0ml). Phantom validation showed good agreement between the proposed method and timer\u2010and\u2010beaker flow volumes (0\u00b74\u00a0\u00b1\u00a02\u00b77\u00a0ml). In conclusion, the proposed semi\u2010automatic vessel segmentation algorithm can be used for efficient analysis of flow and shunt volumes in the aorta and pulmonary artery.<\/jats:p>","DOI":"10.1111\/cpf.12582","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T14:49:45Z","timestamp":1558190985000},"page":"327-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A new vessel segmentation algorithm for robust blood flow quantification from two\u2010dimensional phase\u2010contrast magnetic resonance images"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8023-5026","authenticated-orcid":false,"given":"Sebastian","family":"Bidhult","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Skane University Hospital Lund University Lund Sweden"},{"name":"Department of Biomedical Engineering Faculty of Engineering Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0041-9357","authenticated-orcid":false,"given":"Erik","family":"Hedstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Skane University Hospital Lund University Lund Sweden"},{"name":"Department of Clinical Sciences Lund Diagnostic Radiology Skane University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-5250","authenticated-orcid":false,"given":"Marcus","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Skane University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"T\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Skane University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Steding\u2010Ehrenborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Skane University Hospital Lund University Lund Sweden"},{"name":"Department of Health Sciences Physiotherapy Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Arheden","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Skane University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony H.","family":"Aletras","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Skane University Hospital Lund University Lund Sweden"},{"name":"Laboratory of Computing, Medical Informatics and Biomedical \u2013 Imaging Technologies School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einar","family":"Heiberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Skane University Hospital Lund University Lund Sweden"},{"name":"Department of Biomedical Engineering Faculty of Engineering Lund University Lund Sweden"},{"name":"Wallenberg Center for Molecular Medicine Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10455"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.211.2.r99ma43453"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-018-0509-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0190-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-51"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-6111(96)00010-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/1932409"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-12-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24338"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1109\/CIC.2005.1588172"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2342-10-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22124"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00133570"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199907)10:1<41::AID-JMRI6>3.0.CO;2-J"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/48\/15\/310"},{"key":"e_1_2_9_18_1","first-page":"281","volume-title":"Proceedings of the 5th Berkeley Symposium on Mathematical Statistics and Probability","author":"MacQueen JB","year":"1967"},{"key":"e_1_2_9_19_1","volume-title":"MATLAB version 8.3.0.532","author":"MATLAB","year":"2014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198609000-00001"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786440109462720"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014394626363"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew176"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25683"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/970357"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zemedi.2008.10.011"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.12582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cpf.12582","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.12582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T17:17:37Z","timestamp":1694279857000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpf.12582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,6]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/cpf.12582"],"URL":"https:\/\/doi.org\/10.1111\/cpf.12582","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"value":"1475-0961","type":"print"},{"value":"1475-097X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,6]]},"assertion":[{"value":"2019-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}