{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:30Z","timestamp":1787014050454,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autonomic dysfunction (AD) and cardiopulmonary exercise testing (CPET) parameters have been associated with masked heart failure with preserved ejection fraction (HFpEF) in the general population. Their clinical significance for masked HFpEF in chronic obstructive pulmonary disease (COPD) is however elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of the study was to determine the prevalence, correlation and clinical significance of AD and CPET with masked HFpEF, in non\u2010severe COPD patients, complaining of exertional dyspnoea, without clinically overt cardio\u2010vascular (CV) comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We applied CPET and echocardiography in 68 COPD subjects. Echocardiography was performed before CPET and 1\u20132\u00a0min after peak exercise. Patients were divided into two groups: patients with and without masked HFpEF. Peak E\/e\u2032 \u2013 15 was applied as a cut\u2010off. Chronotropic incompetence (CI) was assumed if both failure to reach the target heart rate (HR) on exercise and diminished heart rate reserve &lt;80% occurred. Abnormal HR recovery (HRR) was taken if the decline is &lt;12 beats within the first minute after exercise cessation. Univariate regression showed association between masked HFpEF, HRR, VO2, VO2 at AT, oxygen pulse and VE\/VCO2 slope. The multivariate regression demonstrated HRR as the only independent predictor of masked HFpEF \u2013 (OR 10.28; 95% CI (3.55\u201329.80)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Abnormal HRR is the only independent predictor of masked HFpEF in non\u2010severe COPD patients. Despite of being associated with masked HFpEF, the lower VO2, lower oxygen pulse, higher VE\/VCO2 slope and lower exercise load seem to be the consequences, rather than the triggers for it.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cpf.12623","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T09:47:29Z","timestamp":1582105649000},"page":"224-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Autonomic dysfunction, cardio\u2010pulmonary exercise testing and masked heart failure with preserved ejection fraction in non\u2010severe chronic obstructive pulmonary disease"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-3438","authenticated-orcid":false,"given":"Radostina","family":"Cherneva","sequence":"first","affiliation":[{"name":"Saint Sophia University Hospital of Pulmonary Diseases Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Denchev","sequence":"additional","affiliation":[{"name":"Medical Institute of the Ministry of Interior Sofia Bulgaria<?oxy_comment_start comment=\"AUTHOR: Please check the details of the corresponding author.\"?><?oxy_comment_end?><?oxy_comment_start comment=\"radostina cherneva cherneva_radost@yahoo.comUniversity Hospital St Sophia, Sofia, Bulgariadata is correct\"?><?oxy_comment_end?>"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1196-2307","authenticated-orcid":false,"given":"Zheyna V.","family":"Cherneva","sequence":"additional","affiliation":[{"name":"Medical Institute of the Ministry of Interior Sofia Bulgaria<?oxy_comment_start comment=\"AUTHOR: Please check the details of the corresponding author.\"?><?oxy_comment_end?><?oxy_comment_start comment=\"radostina cherneva cherneva_radost@yahoo.comUniversity Hospital St Sophia, Sofia, Bulgariadata is correct\"?><?oxy_comment_end?>"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.167.2.211"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0775"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3618"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-5-16"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp022709"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.74.1.27"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808836"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(06)08"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4065\/77.1.45"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10151"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes078"},{"key":"e_1_2_7_13_1","first-page":"1015","article-title":"Left ventricular structure and remodeling in patients with COPD","volume":"11","author":"Giovanna P.","year":"2016","journal-title":"International Journal of Chronic Obstructive Pulmonary Disease"},{"key":"e_1_2_7_14_1","volume-title":"GOLD strategy for diagnosis, management and prevention of chronic obstructive pulmonary disease. 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