{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:10:40Z","timestamp":1762459840606,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Impairments in several markers of the cardiovascular system have been described in impaired glucose tolerance (IGT) and diabetes, but the relative importance of those is not known. We aimed to investigate which cardiovascular markers were most closely linked to an impaired glucose control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In a population\u2010based study of individuals all aged 50\u00a0years, the Prospective study of Obesity, Energy and Metabolism (POEM), 502 subjects were thoroughly investigated regarding endothelial function, arterial compliance, heart rate variability, arterial blood flow and atherosclerosis, performance at an exercise test with gas exchange (VO<jats:sub>2<\/jats:sub> and VCO<jats:sub>2<\/jats:sub>), left ventricular structure and function, lung function and multiple measurements of blood pressure. Based on an oral glucose tolerance test (OGTT), the participants were grouped into normal, IGT and diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of all haemodynamic and structural variables analysed, an impaired glucose control was most closely related to resting heart rate (based on chi\u2010square value at ANOVA). Heart rate was followed by maximal workload, VO<jats:sub>2<\/jats:sub> recovery 5\u00a0min following exercise, reflectance index at pulse wave analysis, manual systolic blood pressure, ambulatory pulse and pulse pressure, echogenicity of carotid intima\u2010media complex at ultrasound, and pulse wave velocity (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0005 for all variables). All of these variables still showed <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05 versus an impaired glucose control following adjustment for BMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Of multiple measured cardiovascular markers, resting heart rate was most closely related to an impaired glucose control. Also exercise capacity and the recovery in VO<jats:sub>2<\/jats:sub> following exercise were amongst the top\u2010ranked cardiovascular impairments linked to an impaired glucose control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12634","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T20:24:27Z","timestamp":1587068667000},"page":"257-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impaired glucose control is associated with multiple cardiovascular impairments"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-8542","authenticated-orcid":false,"given":"Lars","family":"Lind","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-016-0235-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01661.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1306295"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.20.2495"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-3-200708070-00167"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.06.033"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0557-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3095"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283619d50"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12570"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-019-01344-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"issue":"8","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/BF00429099","article-title":"Impaired endothelium\u2010dependent and independent vasodilation in patients with type 2 (non\u2010insulin\u2010dependent) diabetes mellitus","volume":"35","author":"McVeigh G. 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