{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:54:50Z","timestamp":1747184090475,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010125","name":"Jalmari ja Rauha Ahokkaan S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The eucapnic voluntary hyperventilation (EVH) testing is a diagnostic tool for diagnostics of exercise\u2010induced bronchoconstriction; while the testing has become more common among children, data on the test's feasibility among children remain limited. Our aim was to investigate EVH testing feasibility among children, diagnostic testing cut\u2010off values, and which factors affect testing outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 134 patients aged 10\u201316\u00a0years with a history of exercise\u2010induced dyspnoea and 100 healthy control children to undergo 6\u2010min EVH testing. Testing feasibility was assessed by the children's ability to achieve \u226570% of the target minute ventilation of 30 times forced expiratory volume in 1\u00a0s (FEV1). Bronchoconstriction was assessed as a minimum of 8%, 10%, 12%, 15% or 20% fall in FEV1. Patient characteristics were correlated with EVH outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 98% of the children reached \u226570%, 88% reached \u226580%, 79% reached \u226590% and 62% reached \u2265100% of target ventilation in EVH testing; of children with a history of exercise\u2010induced dyspnoea, the decline percentages were as follows: 24% (\u22658% fall), 17% (\u226510% fall), 10% (\u226512% fall), 6% (\u226515% fall) and 5% (\u226520% fall) in FEV1, compared to 11%, 4%, 3%, 1% and 0% among the healthy controls, respectively. Healthy controls and boys performed testing at higher ventilation rates (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Eucapnic voluntary hyperventilation testing is feasible among children aged 10\u201316\u00a0years and has diagnostic value in evaluating exercise\u2010induced dyspnoea among children. A minimum 10% fall in FEV1 is a good diagnostic cut\u2010off value. Disease status appears to be important covariates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12647","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T14:09:50Z","timestamp":1591193390000},"page":"343-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cut\u2010off values to evaluate exercise\u2010induced asthma in eucapnic voluntary hyperventilation test for children"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-455X","authenticated-orcid":false,"given":"Janne","family":"Burman","sequence":"first","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-9904","authenticated-orcid":false,"given":"Varpu","family":"Elenius","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Turku University Hospital and University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Lukkarinen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Turku University Hospital and University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Kuusela","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-3111","authenticated-orcid":false,"given":"Mika 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