{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:54:53Z","timestamp":1747184093536,"version":"3.40.5"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013499","name":"Allergias\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013499","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010125","name":"Jalmari ja Rauha Ahokkaan S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Exhaled nitric oxide (FeNO) measurements and eucapnic voluntary hyperventilation (EVH) tests have been used as diagnostic tools for asthma. Data on the impact of hyperventilation on the level of FeNO are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate whether EVH tests affect the level of FeNO in children aged 10\u201316\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 234 children aged 10\u201316\u00a0years had a 6\u2010min EVH test performed. In total, FeNO values for 153 of 234 children were measured before the test and within 15\u00a0min after the test. According to a baseline FeNO level of 20\u00a0ppb, children were divided into two groups: those with low values (FeNO\u00a0&lt;\u00a020\u00a0ppb) and those with high values (FeNO\u00a0\u2265\u00a020\u00a0ppb).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of the children was 13.4\u00a0years (interquartile range 12.3\u201315.3\u00a0years); 58% were boys and 42% were girls. Of these children, 51% were sensitized to aeroallergens. In 101 of 153 children (66%), the FeNO values decreased after the EVH test. In children with low and high baseline levels, the median level of FeNO decreased after the EVH test: 10.5\u00a0ppb before versus 9.5\u00a0ppb after (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.011), and 31.0\u00a0ppb before versus 28.0\u00a0ppb after (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.011), respectively. The decrease in FeNO after EVH test was not associated with induced bronchoconstriction expressed as a change in FEV1 (<jats:italic>R<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a0.19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The EVH test decreases FeNO levels. Therefore, FeNO should be measured before an EVH test is performed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12673","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T19:28:43Z","timestamp":1603826923000},"page":"1-3","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eucapnic voluntary hyperventilation test decreases exhaled nitric oxide level in children"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-455X","authenticated-orcid":false,"given":"Janne","family":"Burman","sequence":"first","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5087-1160","authenticated-orcid":false,"given":"Pekka","family":"Malmberg","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-9904","authenticated-orcid":false,"given":"Varpu","family":"Elenius","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Turku University Hospital and University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Lukkarinen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Turku University Hospital and University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Kuusela","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-3111","authenticated-orcid":false,"given":"Mika","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3204-5639","authenticated-orcid":false,"given":"Sami","family":"Remes","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-5362","authenticated-orcid":false,"given":"Tuomas","family":"Jartti","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Turku University Hospital and University of Turku Turku Finland"},{"name":"Department of Paediatrics Oulu University Hospital and University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054521"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11ST"},{"key":"e_1_2_4_4_1","doi-asserted-by":"crossref","first-page":"1801033","DOI":"10.1183\/13993003.01033-2018","article-title":"ERS technical standard on bronchial challenge testing: Pathophysiology and methodology of indirect airway challenge testing","volume":"15","author":"Hallstrand T. S.","year":"2018","journal-title":"European Respiratory Journal"},{"key":"e_1_2_4_5_1","first-page":"CD011439","article-title":"Exhaled nitric oxide levels to guide treatment for children with asthma (Review)","volume":"11","author":"Petsky H. L.","year":"2016","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_4_6_1","first-page":"30","article-title":"Cough and exhaled nitric oxide levels: What happens with exercise?","volume":"24","author":"Petsy H. L.","year":"2013","journal-title":"Frontiers in Pediatrics"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.12673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cpf.12673","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.12673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T04:27:14Z","timestamp":1693801634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpf.12673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,11]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/cpf.12673"],"URL":"https:\/\/doi.org\/10.1111\/cpf.12673","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"type":"print","value":"1475-0961"},{"type":"electronic","value":"1475-097X"}],"subject":[],"published":{"date-parts":[[2020,11,11]]},"assertion":[{"value":"2020-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}