{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:53:34Z","timestamp":1769162014511,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T00:00:00Z","timestamp":1606608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The inclusion of scintigraphy in the diagnostic algorithm for gastroesophageal reflux is controversial due to variability in methodology and reporting. A novel scintigraphic reflux study has been developed and validated against the current standards for the diagnosis of gastroesophageal reflux disease (GORD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare a new scintigraphic reflux test against historic techniques and standardised diagnostic reference tests for gastroesophageal reflux disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Paired scintigraphic studies were conducted in seventeen patients. All patients underwent at least one other standardised diagnostic reflux test such as 24\u2010 hour oesophageal impedance\/ pH, and oesophageal manometry, barium swallow, gastroscopy or the Peptest. Patients inadvertently presented at sites B for scintigraphic reflux testing rather than at Site A which was part of an approved study. The findings from sites B did not correlate with clinical symptoms and other diagnostic reference tests from GORD. These studies were then repeated at Site A with approval from the patients. A second reflux study was performed at site A, utilising a novel technique with the capability of assessing oesophageal and extra\u2010oesophageal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Site A technique shows good concordance with the reference diagnostic tests with an accuracy of 82.4% and kappa of 0.64 (SE: 0.16, <jats:italic>p<\/jats:italic> = 0.00). Site B had an overall accuracy of 47.1% and kappa of 0.066 (SE: 0.068, <jats:italic>p<\/jats:italic> = 0.45).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Site A technique shows higher accuracy than either site B or the historic reflux techniques. It has characteristics that make it an effective screening tool for assessment of local oesophageal disease and its extraoesophageal manifestations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12677","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T10:30:04Z","timestamp":1604658604000},"page":"136-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A transformational change in scintigraphic gastroesophageal reflux studies: A comparison with historic techniques"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7234-1267","authenticated-orcid":false,"given":"Leticia","family":"Burton","sequence":"first","affiliation":[{"name":"CNI Molecular Imaging &amp; University of Notre Dame Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Joffe","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Royal North Shore Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas W","family":"Mackey","sequence":"additional","affiliation":[{"name":"CNI Molecular Imaging &amp; University of Notre Dame Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Van der Wall","sequence":"additional","affiliation":[{"name":"CNI Molecular Imaging &amp; University of Notre Dame Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory L","family":"Falk","sequence":"additional","affiliation":[{"name":"Sydney Heartburn Clinic Concord Hospital &amp; University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/snuc.2001.26205"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4274\/mirt.galenos.2019.30085"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4274\/mirt.10438"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200304000-00012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118512074.ch20"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197610000-00009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-19426-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i12.3619"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.12.1534"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-020-00726-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529108996505"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12914"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200108000-00003"},{"key":"e_1_2_7_16_1","first-page":"547","article-title":"Current diagnosis and management of suspected reflux symptoms refractory to proton pump inhibitor therapy","volume":"10","author":"Richter J. 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