{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:56:47Z","timestamp":1791647807749,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the absence of mitral valve disease, increased left atrial volume (LAV) is a marker of diastolic dysfunction and long\u2010standing elevated left ventricle (LV) pressure. The aim of this study was to assess the role of increased baseline LAV in predicting clinical outcome of patients presenting with acute coronary syndrome (ACS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically searched all electronic databases up to September 2020 in order to select clinical trials and observational studies, which assessed the predictive role of LAV indexed (LAVI) on clinical outcome in patients with ACS. Primary clinical endpoints were as follows: major adverse cardiac events (MACE), all\u2010cause mortality and hospitalization. Secondary endpoints were in\u2010hospital complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2,705 patients from 11 cohort studies with a mean follow\u2010up 18.7\u00a0\u00b1\u00a09.8\u00a0months were included in the meta\u00adanalysis. Patients with low LAVI had low risk for MACE (15.9% vs. 33.7%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), long\u2010term all\u2010cause mortality (9.14% vs. 18.1%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), short\u2010term mortality (3.31% vs. 9.38%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) and lower hospitalization rate (11.6% vs. 25.5%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) compared to patients with increased LAVI. Atrial fibrillation and cardiogenic shock as in\u2010hospital events were lower (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05 for all) in patients with low LAVI but ventricular fibrillation\/tachycardia was not different between groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.14).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased LAVI is an independent predictor of outcome in patients with ACS. Thus, assessment of LA index in these patients is important for better risk stratification and guidance towards optimum clinical management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12689","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T08:24:40Z","timestamp":1609230280000},"page":"128-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic value of left atrial volume index in acute coronary syndrome: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"41","author":[{"given":"Artan","family":"Ahmeti","sequence":"first","affiliation":[{"name":"Clinic of Cardiology University Clinical Centre of Kosovo Prishtina Kosovo"},{"name":"Medical Faculty University of Prishtina Prishtina Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feriz S.","family":"Byty\u00e7i","sequence":"additional","affiliation":[{"name":"Main Family Medical Center Prishtina Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Bielecka\u2010Dabrowa","sequence":"additional","affiliation":[{"name":"Department of Hypertension Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-4257","authenticated-orcid":false,"given":"Ibadete","family":"Byty\u00e7i","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology University Clinical Centre of Kosovo Prishtina Kosovo"},{"name":"Institute of Public Health and Clinical Medicine Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Henein","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Medicine Ume\u00e5 University Ume\u00e5 Sweden"},{"name":"Molecular and Clinic Research Institute St George University London UK"},{"name":"Brunel University London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.048"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041365"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2011.227678"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90787-2"},{"key":"e_1_2_6_7_1","first-page":"26","article-title":"Left atrial volume index: As a predictor of early in\u2010hospital major adverse cardiovascular events in acute coronary syndrome","volume":"13","author":"Badiger S.","year":"2019","journal-title":"Journal of Clinical & Diagnostic Research."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(14)80213-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.062"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13306"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","DOI":"10.5114\/aoms.2019.91511","article-title":"Left atrial volume index predicts response to cardiac resynchronisation therapy: A systematic review and meta\u2010analysis","author":"Byty\u00e7i I.","year":"2020","journal-title":"Archives of Medical Science"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12587"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.3.236"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2018.01.012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.025"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9820470"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2012.02.015"},{"key":"e_1_2_6_18_1","volume-title":"Cochrane handbook for systematic reviews of interventions version 5.0.2","author":"Higgins J. 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